Comparative study of two routes of administration of 5-aminolevulinic acid (oral and intratumoral via) and their effect on the accumulation of PpIX in tissues in murine model of breast cancer

G. González-Agüero; E. Ramón-Gallegos

doi:10.1063/1.4764630

Comparative study of two routes of administration of 5-aminolevulinic acid (oral and intratumoral via) and their effect on the accumulation of PpIX in tissues in murine model of breast cancer

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Resumen

Protoporphyrin IX (PpIX) is a photosensitizer synthesized from 5-aminolevulinic acid (ALA) that has been used in photodynamic therapy (PDT) as a promising treatment for many types of cancer. In this work it was quantified the accumulation of PpIX in tumors and in different tissues of female mice (nu/nu) inoculated with breast cancer cells. Two routes of administration of ALA: gastric probe and intratumoral injection were used to find optimum time of accumulation and the via that induce the higher quantity of PpIX to improve the efficiency of PDT. The results show that the accumulation of PpIX using the intratumoral via is two times bigger than the oral via in tumors at 8 h of treatment. The concentrations obtained in the different tissues are not physiologically significant.

Idioma original	Inglés
Título de la publicación alojada	Medical Physics - Twelfth Mexican Symposium on Medical Physics
Páginas	158-160
Número de páginas	3
DOI	https://doi.org/10.1063/1.4764630
Estado	Publicada - 2012
Publicado de forma externa	Sí
Evento	12th Mexican Symposium on Medical Physics - Oaxaca, México Duración: 16 mar. 2012 → 19 mar. 2012

Serie de la publicación

Nombre	AIP Conference Proceedings
Volumen	1494
ISSN (versión impresa)	0094-243X
ISSN (versión digital)	1551-7616

Conferencia

Conferencia	12th Mexican Symposium on Medical Physics
País/Territorio	México
Ciudad	Oaxaca
Período	16/03/12 → 19/03/12

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10.1063/1.4764630

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González-Agüero, G., & Ramón-Gallegos, E. (2012). Comparative study of two routes of administration of 5-aminolevulinic acid (oral and intratumoral via) and their effect on the accumulation of PpIX in tissues in murine model of breast cancer. En Medical Physics - Twelfth Mexican Symposium on Medical Physics (pp. 158-160). (AIP Conference Proceedings; Vol. 1494). https://doi.org/10.1063/1.4764630

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abstract = "Protoporphyrin IX (PpIX) is a photosensitizer synthesized from 5-aminolevulinic acid (ALA) that has been used in photodynamic therapy (PDT) as a promising treatment for many types of cancer. In this work it was quantified the accumulation of PpIX in tumors and in different tissues of female mice (nu/nu) inoculated with breast cancer cells. Two routes of administration of ALA: gastric probe and intratumoral injection were used to find optimum time of accumulation and the via that induce the higher quantity of PpIX to improve the efficiency of PDT. The results show that the accumulation of PpIX using the intratumoral via is two times bigger than the oral via in tumors at 8 h of treatment. The concentrations obtained in the different tissues are not physiologically significant.",

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González-Agüero, G & Ramón-Gallegos, E 2012, Comparative study of two routes of administration of 5-aminolevulinic acid (oral and intratumoral via) and their effect on the accumulation of PpIX in tissues in murine model of breast cancer. En Medical Physics - Twelfth Mexican Symposium on Medical Physics. AIP Conference Proceedings, vol. 1494, pp. 158-160, 12th Mexican Symposium on Medical Physics, Oaxaca, México, 16/03/12. https://doi.org/10.1063/1.4764630

Comparative study of two routes of administration of 5-aminolevulinic acid (oral and intratumoral via) and their effect on the accumulation of PpIX in tissues in murine model of breast cancer. / González-Agüero, G.; Ramón-Gallegos, E.
Medical Physics - Twelfth Mexican Symposium on Medical Physics. 2012. p. 158-160 (AIP Conference Proceedings; Vol. 1494).

Producción científica: Capítulo del libro/informe/acta de congreso › Contribución a la conferencia › revisión exhaustiva

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AB - Protoporphyrin IX (PpIX) is a photosensitizer synthesized from 5-aminolevulinic acid (ALA) that has been used in photodynamic therapy (PDT) as a promising treatment for many types of cancer. In this work it was quantified the accumulation of PpIX in tumors and in different tissues of female mice (nu/nu) inoculated with breast cancer cells. Two routes of administration of ALA: gastric probe and intratumoral injection were used to find optimum time of accumulation and the via that induce the higher quantity of PpIX to improve the efficiency of PDT. The results show that the accumulation of PpIX using the intratumoral via is two times bigger than the oral via in tumors at 8 h of treatment. The concentrations obtained in the different tissues are not physiologically significant.

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González-Agüero G, Ramón-Gallegos E. Comparative study of two routes of administration of 5-aminolevulinic acid (oral and intratumoral via) and their effect on the accumulation of PpIX in tissues in murine model of breast cancer. En Medical Physics - Twelfth Mexican Symposium on Medical Physics. 2012. p. 158-160. (AIP Conference Proceedings). doi: 10.1063/1.4764630

Comparative study of two routes of administration of 5-aminolevulinic acid (oral and intratumoral via) and their effect on the accumulation of PpIX in tissues in murine model of breast cancer

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