TY - JOUR
T1 - Collagen and elastin scaffold by electrospinning for skin tissue engineering applications
AU - Jimenez Vazquez, Josué
AU - San Martín Martínez, Eduardo
N1 - Publisher Copyright:
© Copyright Materials Research Society 2019.
PY - 2019/8/28
Y1 - 2019/8/28
N2 - In recent years, tissue engineering has helped to reduce hospital stays and deaths caused by skin wounds. Scaffolds are one of the main factors that influence the success of any tissue graft. Collagen is one of the main components of the extracellular matrix, and there has been much interest in new sources for application as a biomaterial. In this work, a tissue engineering scaffold was developed using the electrospinning technique. The chicken skin was used as an alternative source to obtain collagen. The combination of this collagen with elastin was successfully electrospun, and a distribution of diameters was obtained, less than 100 nm. In vitro tests showed the adhesion and proliferation of the cells, as well as an absence of cytotoxicity from non-cross-linked scaffolds and scaffolds that were cross-linked with carbonyldiimidazole. The structure and composition of the developed scaffolding provide a favorable environment for cell growth and generating a skin substitute.
AB - In recent years, tissue engineering has helped to reduce hospital stays and deaths caused by skin wounds. Scaffolds are one of the main factors that influence the success of any tissue graft. Collagen is one of the main components of the extracellular matrix, and there has been much interest in new sources for application as a biomaterial. In this work, a tissue engineering scaffold was developed using the electrospinning technique. The chicken skin was used as an alternative source to obtain collagen. The combination of this collagen with elastin was successfully electrospun, and a distribution of diameters was obtained, less than 100 nm. In vitro tests showed the adhesion and proliferation of the cells, as well as an absence of cytotoxicity from non-cross-linked scaffolds and scaffolds that were cross-linked with carbonyldiimidazole. The structure and composition of the developed scaffolding provide a favorable environment for cell growth and generating a skin substitute.
KW - biomedical
KW - biomimetic (assembly)
KW - cellular
KW - collagen
KW - elastin
KW - electrospinning
KW - scaffold
KW - skin
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85070381044&partnerID=8YFLogxK
U2 - 10.1557/jmr.2019.233
DO - 10.1557/jmr.2019.233
M3 - Artículo
SN - 0884-2914
VL - 34
SP - 2819
EP - 2827
JO - Journal of Materials Research
JF - Journal of Materials Research
IS - 16
ER -