TY - JOUR
T1 - Chemical profile and pharmacological effects of the resin and essential oil from Bursera slechtendalii
T2 - A medicinal “copal tree” of southern Mexico
AU - Villa-Ruano, Nemesio
AU - Pacheco-Hernández, Yesenia
AU - Becerra-Martínez, Elvia
AU - Zárate-Reyes, José Alejo
AU - Cruz-Durán, Ramiro
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/7
Y1 - 2018/7
N2 - This study reports on the volatile profile and pharmacological activities of the essential oil and resin from Bursera slechtendalii, an aromatic medicinal tree commercialized in southern Mexico. The essential oil contained 25 volatiles including p-cymen-8-ol (25.4–35.7%), n-hexyl hexanoate (6.8–17.6%) and n-octyl hexanoate (7.6–14.8%), whereas the crystallized resin contained 14 volatiles, including n-octyl acetate (29.6–34.2%), limonene (15.8–18.7%) and n-octyl butyrate (12.6–17-6%). The inhalation of vapors from the resin and essential oil caused a significant anxiolytic-like effect (p <.01) in ICR mice after 20 min of exposure at a dose of 50–150 mg L−1. The prolonged inhalation of the essential oil (for 40 days, for 15 min, twice a day) produced a significant decrease (p <.01) in total cholesterol and LDL-c content as well as an increase of HDL-c levels in the same murine model. Interestingly, levels of hepatic lipid hydroperoxide decreased, whereas the hepatic activity of superoxide dismutase and glutathione peroxidase was significantly enhanced (P <.05). The detection of p-cymen-8-ol and n-octyl acetate in the plasma of mice strongly suggests their bioavailability and possible role in the biological activities described herein. Also, both the resin and essential oil from B. slechtendalii, as well as their main volatiles, showed a potent repellence activity against Aedes aegypti (p <.01).
AB - This study reports on the volatile profile and pharmacological activities of the essential oil and resin from Bursera slechtendalii, an aromatic medicinal tree commercialized in southern Mexico. The essential oil contained 25 volatiles including p-cymen-8-ol (25.4–35.7%), n-hexyl hexanoate (6.8–17.6%) and n-octyl hexanoate (7.6–14.8%), whereas the crystallized resin contained 14 volatiles, including n-octyl acetate (29.6–34.2%), limonene (15.8–18.7%) and n-octyl butyrate (12.6–17-6%). The inhalation of vapors from the resin and essential oil caused a significant anxiolytic-like effect (p <.01) in ICR mice after 20 min of exposure at a dose of 50–150 mg L−1. The prolonged inhalation of the essential oil (for 40 days, for 15 min, twice a day) produced a significant decrease (p <.01) in total cholesterol and LDL-c content as well as an increase of HDL-c levels in the same murine model. Interestingly, levels of hepatic lipid hydroperoxide decreased, whereas the hepatic activity of superoxide dismutase and glutathione peroxidase was significantly enhanced (P <.05). The detection of p-cymen-8-ol and n-octyl acetate in the plasma of mice strongly suggests their bioavailability and possible role in the biological activities described herein. Also, both the resin and essential oil from B. slechtendalii, as well as their main volatiles, showed a potent repellence activity against Aedes aegypti (p <.01).
KW - Anxiolytic
KW - Bursera slechtendalii
KW - Copal tree
KW - Hypocholesterolemic
KW - Insect repellence
KW - Volatiles
UR - http://www.scopus.com/inward/record.url?scp=85047195013&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2018.05.009
DO - 10.1016/j.fitote.2018.05.009
M3 - Artículo
C2 - 29777752
SN - 0367-326X
VL - 128
SP - 86
EP - 92
JO - Fitoterapia
JF - Fitoterapia
ER -