TY - JOUR
T1 - Causal association of haptoglobin with obesity in mexican children
T2 - A mendelian randomization study
AU - Vázquez-Moreno, Miguel
AU - Locia-Morales, Daniel
AU - Perez-Herrera, Aleyda
AU - Gomez-Diaz, Rita A.
AU - Gonzalez-Dzib, Roxana
AU - Valdez-González, Adriana L.
AU - Flores-Alfaro, Eugenia
AU - Corona-Salazar, Perla
AU - Suarez-Sanchez, Fernando
AU - Gomez-Zamudio, Jaime
AU - Valladares-Salgado, Adan
AU - Wacher-Rodarte, Niels
AU - Cruz, Miguel
AU - Meyre, David
N1 - Publisher Copyright:
© 2020 Endocrine Society. All rights reserved.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Context: Little is known about the association between haptoglobin level and cardiometabolic traits. A previous genome-wide association study identified rs2000999 in the HP gene as the stronger genetic contributor to serum haptoglobin level in European populations. Objective and Design: We investigated the association of HP rs2000999 with serum haptoglobin and childhood and adult obesity in up to 540/697 and 592/691 Mexican cases and controls, respectively. Anthropometric and biochemical data were collected. Serum haptoglobin was measured by an immunoturbidimetry assay. HP rs2000999 was genotyped using the TaqMan technology. Mendelian randomization analysis was performed using the Wald and inverse variance weighting methods. Results: Haptoglobin level was positively associated with childhood and adult obesity. HP rs2000999 G allele was positively associated with haptoglobin level in children and adults. HP rs2000999 G allele was positively associated with childhood but not adult obesity. The association between HP rs2000999 and childhood obesity was removed after adjusting for haptoglobin level. In a Mendelian randomization analysis, haptoglobin level genetically predicted by HP rs2000999 showed a significant causal effect on childhood obesity by the Wald and inverse variance weighting methods. Conclusion: Our data provide evidence for the first time for a causal positive association between serum haptoglobin level and childhood obesity in the Mexican population. Our study contributes to the genetic elucidation of childhood obesity and proposes haptoglobin as an important biomarker and treatment target for obesity.
AB - Context: Little is known about the association between haptoglobin level and cardiometabolic traits. A previous genome-wide association study identified rs2000999 in the HP gene as the stronger genetic contributor to serum haptoglobin level in European populations. Objective and Design: We investigated the association of HP rs2000999 with serum haptoglobin and childhood and adult obesity in up to 540/697 and 592/691 Mexican cases and controls, respectively. Anthropometric and biochemical data were collected. Serum haptoglobin was measured by an immunoturbidimetry assay. HP rs2000999 was genotyped using the TaqMan technology. Mendelian randomization analysis was performed using the Wald and inverse variance weighting methods. Results: Haptoglobin level was positively associated with childhood and adult obesity. HP rs2000999 G allele was positively associated with haptoglobin level in children and adults. HP rs2000999 G allele was positively associated with childhood but not adult obesity. The association between HP rs2000999 and childhood obesity was removed after adjusting for haptoglobin level. In a Mendelian randomization analysis, haptoglobin level genetically predicted by HP rs2000999 showed a significant causal effect on childhood obesity by the Wald and inverse variance weighting methods. Conclusion: Our data provide evidence for the first time for a causal positive association between serum haptoglobin level and childhood obesity in the Mexican population. Our study contributes to the genetic elucidation of childhood obesity and proposes haptoglobin as an important biomarker and treatment target for obesity.
KW - HP rs2000999 polymorphism; Mendelian randomization
KW - Mexican children and adults
KW - Obesity
KW - Serum haptoglobin
KW - Serum lipids
UR - http://www.scopus.com/inward/record.url?scp=85085714432&partnerID=8YFLogxK
U2 - 10.1210/clinem/dgaa213
DO - 10.1210/clinem/dgaa213
M3 - Artículo
C2 - 32309857
SN - 0021-972X
VL - 105
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 7
M1 - dgaa213
ER -