Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats

Luis Cobos-Puc, Pablo Urbina-Ruiz, Jorge Pacheco-Rosado, Hilda Aguayo-Morales, Araceli Sánchez-López, David Centurión

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Background: Patients suffering from hypothyroidism tend to develop diastolic hypertension. 5-Hydroxytryptamine (5-HT) is an amine that contributes to the maintenance of the blood pressure through central and peripheral 5-HT receptors. Curiously, the hypothyroidism alters the density of the 5-HT receptors in rodent brains. Aim of the study: Analyze the effect of the methimazole-induced hypothyroidism on the peripheral cardiovascular responses elicited by 5-HT. Methods: The vasopressor and tachycardic responses to 5-HT (3-300 μg/kg), and the vasodepressor responses to 5-HT, 5-carboxamidotryptamine (5-CT, 0.001–0.1 μg/kg), isoprenaline (0.03–1 μg/kg) and acetylcholine (ACh, 0.03–3 μg/kg), during an infusion of methoxamine, were determined in pithed hypothyroid rats. Results: The tachycardic and vasopressor responses to 5-HT and the vasodepressor responses to 5-CT and ACh remained unaffected, the vasodepressor response to 5-HT reduced, and the vasodepressor response to isoprenaline enhanced and reduced at the lowest and highest dose, respectively. Conclusion: These results suggest that hypothyroidism impairs the vasodepressor response to 5-HT, which could contribute to hypothyroidism-induced hypertension.

Idioma originalInglés
Páginas (desde-hasta)310-316
Número de páginas7
PublicaciónArchives of Medical Research
Volumen51
N.º4
DOI
EstadoPublicada - may. 2020

Huella

Profundice en los temas de investigación de 'Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats'. En conjunto forman una huella única.

Citar esto