TY - JOUR
T1 - Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats
AU - Cobos-Puc, Luis
AU - Urbina-Ruiz, Pablo
AU - Pacheco-Rosado, Jorge
AU - Aguayo-Morales, Hilda
AU - Sánchez-López, Araceli
AU - Centurión, David
N1 - Publisher Copyright:
© 2020 IMSS
PY - 2020/5
Y1 - 2020/5
N2 - Background: Patients suffering from hypothyroidism tend to develop diastolic hypertension. 5-Hydroxytryptamine (5-HT) is an amine that contributes to the maintenance of the blood pressure through central and peripheral 5-HT receptors. Curiously, the hypothyroidism alters the density of the 5-HT receptors in rodent brains. Aim of the study: Analyze the effect of the methimazole-induced hypothyroidism on the peripheral cardiovascular responses elicited by 5-HT. Methods: The vasopressor and tachycardic responses to 5-HT (3-300 μg/kg), and the vasodepressor responses to 5-HT, 5-carboxamidotryptamine (5-CT, 0.001–0.1 μg/kg), isoprenaline (0.03–1 μg/kg) and acetylcholine (ACh, 0.03–3 μg/kg), during an infusion of methoxamine, were determined in pithed hypothyroid rats. Results: The tachycardic and vasopressor responses to 5-HT and the vasodepressor responses to 5-CT and ACh remained unaffected, the vasodepressor response to 5-HT reduced, and the vasodepressor response to isoprenaline enhanced and reduced at the lowest and highest dose, respectively. Conclusion: These results suggest that hypothyroidism impairs the vasodepressor response to 5-HT, which could contribute to hypothyroidism-induced hypertension.
AB - Background: Patients suffering from hypothyroidism tend to develop diastolic hypertension. 5-Hydroxytryptamine (5-HT) is an amine that contributes to the maintenance of the blood pressure through central and peripheral 5-HT receptors. Curiously, the hypothyroidism alters the density of the 5-HT receptors in rodent brains. Aim of the study: Analyze the effect of the methimazole-induced hypothyroidism on the peripheral cardiovascular responses elicited by 5-HT. Methods: The vasopressor and tachycardic responses to 5-HT (3-300 μg/kg), and the vasodepressor responses to 5-HT, 5-carboxamidotryptamine (5-CT, 0.001–0.1 μg/kg), isoprenaline (0.03–1 μg/kg) and acetylcholine (ACh, 0.03–3 μg/kg), during an infusion of methoxamine, were determined in pithed hypothyroid rats. Results: The tachycardic and vasopressor responses to 5-HT and the vasodepressor responses to 5-CT and ACh remained unaffected, the vasodepressor response to 5-HT reduced, and the vasodepressor response to isoprenaline enhanced and reduced at the lowest and highest dose, respectively. Conclusion: These results suggest that hypothyroidism impairs the vasodepressor response to 5-HT, which could contribute to hypothyroidism-induced hypertension.
KW - 5-Hydroxytryptamine
KW - Hypertension
KW - Hypothyroidism
KW - Methimazole
KW - Vasodepressor response
UR - http://www.scopus.com/inward/record.url?scp=85083055049&partnerID=8YFLogxK
U2 - 10.1016/j.arcmed.2020.03.013
DO - 10.1016/j.arcmed.2020.03.013
M3 - Artículo
C2 - 32284200
AN - SCOPUS:85083055049
SN - 0188-4409
VL - 51
SP - 310
EP - 316
JO - Archives of Medical Research
JF - Archives of Medical Research
IS - 4
ER -