TY - JOUR
T1 - Association of physical performance tests with frailty indicators and oxidative stress markers in a sample of a community-dwelling elderly population
AU - Munguia, Levy
AU - Solis, Vannia
AU - Meaney, Eduardo
AU - Ramirez-Sanchez, Israel
AU - Villarreal, Francisco
AU - Perez-Duran, Javier
AU - Rubio-Gayosso, Ivan
AU - Ortiz, Alicia
AU - Ceballos, Guillermo
AU - Najera, Nayelli
N1 - Publisher Copyright:
© 2018, Scientific Publishers of India. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Aim: Frailty is a syndrome that commonly affects the elderly population and is characterized by physical, mental and metabolic decline, increasing the risk for disability and death. The aim of this study was to study the relationship amongst the performance in 6 min walk distance, 2-min step, sit-up, and up and go tests with frailty and its relationship with select, pre-identified factors in a community-dwelling elderly Mexican population. Methods: The study comprised 170 individuals between 65-90 y old from 5 community centres in Mexico City. Frailty was defined using the Fried Frailty Phenotype (FFP) criteria. A set of variables were used to explore associations between mobility and frailty, health conditions, and quality of life. Results: Mean age of participants was 72.6 ± 6.5 y, 82.3% of which were women. The prevalence of frailty was 25.9% (n=44). Frailty was more frequent in women, in persons aged 80 y and over as well as in those demonstrating low performance in the 2-min step, sit-up, and up and go tests. Lipoperoxidation measured as malondialdehyde (MDA) and carbonyl blood concentrations, as markers of oxidative stress, were significantly elevated in frail vs. non-frail subjects Conclusion: Frailty is a common pathology in a sample of the elderly community in Mexico. It is associated to low physical performance, quality of life, body composition and metabolic parameters and high oxidative stress.
AB - Aim: Frailty is a syndrome that commonly affects the elderly population and is characterized by physical, mental and metabolic decline, increasing the risk for disability and death. The aim of this study was to study the relationship amongst the performance in 6 min walk distance, 2-min step, sit-up, and up and go tests with frailty and its relationship with select, pre-identified factors in a community-dwelling elderly Mexican population. Methods: The study comprised 170 individuals between 65-90 y old from 5 community centres in Mexico City. Frailty was defined using the Fried Frailty Phenotype (FFP) criteria. A set of variables were used to explore associations between mobility and frailty, health conditions, and quality of life. Results: Mean age of participants was 72.6 ± 6.5 y, 82.3% of which were women. The prevalence of frailty was 25.9% (n=44). Frailty was more frequent in women, in persons aged 80 y and over as well as in those demonstrating low performance in the 2-min step, sit-up, and up and go tests. Lipoperoxidation measured as malondialdehyde (MDA) and carbonyl blood concentrations, as markers of oxidative stress, were significantly elevated in frail vs. non-frail subjects Conclusion: Frailty is a common pathology in a sample of the elderly community in Mexico. It is associated to low physical performance, quality of life, body composition and metabolic parameters and high oxidative stress.
KW - Elderly
KW - Frailty
KW - Fried frailty phenotype
KW - Oxidative stress
KW - Physical performance
UR - http://www.scopus.com/inward/record.url?scp=85055659906&partnerID=8YFLogxK
U2 - 10.4066/biomedicalresearch.29-18-806
DO - 10.4066/biomedicalresearch.29-18-806
M3 - Artículo
AN - SCOPUS:85055659906
SN - 0970-938X
VL - 29
SP - 3344
EP - 3350
JO - Biomedical Research (India)
JF - Biomedical Research (India)
IS - 17
ER -