TY - JOUR
T1 - Antispasmodic and relaxant activity from the freshwater cyanobacteria Blennothrix ganeshii and Microcoleous lacustris extracts
AU - Gutiérrez, Rosa Martha Pérez
AU - Solis, Rosario Vargas
PY - 2009
Y1 - 2009
N2 - The discovery of novel compounds with pharmaceutical application in cyanobacterias suggests that Blennothrix ganeshii and Microcoleous lacustris Mexican species can be candidates for the bioprocess of target compounds. The antispasmodic effect of hexane, chloroform, methanol and water extracts of B. ganeshii and M. lacustris were studied in vitro in guinea pig ileum against three spasmogens; acetylcholine, histamine and barium chloride. In all cases, the hexane extract produces a significant antispasmodic effect on the contractions of the rat ileum induced by acetylcholine, histamine and barium chloride. The inhibitory concentration for each was determined. These results show that hexane extract of B. ganeshii, and M. lacustris possesses both anticholinergic and antihistaminic properties.
AB - The discovery of novel compounds with pharmaceutical application in cyanobacterias suggests that Blennothrix ganeshii and Microcoleous lacustris Mexican species can be candidates for the bioprocess of target compounds. The antispasmodic effect of hexane, chloroform, methanol and water extracts of B. ganeshii and M. lacustris were studied in vitro in guinea pig ileum against three spasmogens; acetylcholine, histamine and barium chloride. In all cases, the hexane extract produces a significant antispasmodic effect on the contractions of the rat ileum induced by acetylcholine, histamine and barium chloride. The inhibitory concentration for each was determined. These results show that hexane extract of B. ganeshii, and M. lacustris possesses both anticholinergic and antihistaminic properties.
KW - Antispasmodic activity
KW - Blennothrix ganeshii
KW - Cyanobacteria
KW - Microcoleous lacustris
UR - http://www.scopus.com/inward/record.url?scp=73449093889&partnerID=8YFLogxK
M3 - Artículo
SN - 1996-0875
VL - 3
SP - 403
EP - 407
JO - Journal of Medicinal Plants Research
JF - Journal of Medicinal Plants Research
IS - 5
ER -