Antimicrobial activity induced by a steroid-brucine derivative on S. typhi, K. pneumoniae and E. coli

For many years, various drugs have been used for the treatment of infectious diseases but some bacterial microorganisms have induced resistance to several drugs. In the search for an alternative therapy for the infectious diseases, in this study the antibacterial activity of the steroid-brucine derivative against S. typhy, K. pneumoniae and E. coli was evaluated, using as control cefotaxime, gentamicin and ciprofloxacin. The evaluation of antimicrobial effect of the different compounds on the bacterial species was made by the method of microbial minimal inhibitory. The results indicate that bacterial growth of S. typhi was inhibited with cefotaxime, gentamicin, ciprofloxacin, brucine-ethylenediamine derivative and brucine-estradiol conjugate. Other results showed that bacterial growth of E. coli was inhibited with cefotaxime, gentamicin, ciprofloxacin, brucine-ethylenediamine and brucine-estradiol conjugate. Alternative experimental, indicate that bacterial growth of K. pneumoniae was inhibited with cefotaxime, gentamicin, ciprofloxacin, brucine-ethylenediamine derivative and brucine-estradiol conjugate. In conclusion, S. typhi, K. pneumoniae and E. coli were susceptible to gentamicin, cefotaxime, ciprofloxacin, brucine-ethylenediamine derivative and brucine-estradiol conjugate. These phenomenon, involves different molecular mechanism of brucine-ethylenediamine derivative and brucine-estradiol conjugate in comparison with the controls. In addition, the antibacterial activity induced by brucine-estradiol in comparison with the brucine-ethylenediamine derivative can depend of the degree of lipophilicity of these compounds.