TY - JOUR
T1 - Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum
AU - Calzada, Fernando
AU - Barbosa, Elizabeth
AU - Cedillo-Rivera, Roberto
PY - 2003/6
Y1 - 2003/6
N2 - In a continuation of our search for potential antiprotozoal agents from plants, we found that a crude extract from the roots of Lepidium virginicum exhibited antiprotozoal activity against Entamoeba histolytica trophozoites (IC50 of 100.1 μg/mL). Bioassay-guided fractionation resulted in the isolation of one known glucosinolate responsible for such activity. This compound was identified as benzyl glucosinolate. It showed in vitro activity against Entamoeba histolytica strain HM1-IMSS (IC50 of 20.4 μg/mL). The results support the anecdotal reports for the traditional use of L. virginicum roots in the control of diarrhoea and dysentery in the highlands of Chiapas, Mexico.
AB - In a continuation of our search for potential antiprotozoal agents from plants, we found that a crude extract from the roots of Lepidium virginicum exhibited antiprotozoal activity against Entamoeba histolytica trophozoites (IC50 of 100.1 μg/mL). Bioassay-guided fractionation resulted in the isolation of one known glucosinolate responsible for such activity. This compound was identified as benzyl glucosinolate. It showed in vitro activity against Entamoeba histolytica strain HM1-IMSS (IC50 of 20.4 μg/mL). The results support the anecdotal reports for the traditional use of L. virginicum roots in the control of diarrhoea and dysentery in the highlands of Chiapas, Mexico.
KW - Antiamoebic activity
KW - Benzyl glucosinolate
KW - Entamoeba histolytica
KW - Glucosinolate
KW - Lepidium virginicum
UR - http://www.scopus.com/inward/record.url?scp=0038802427&partnerID=8YFLogxK
U2 - 10.1002/ptr.1210
DO - 10.1002/ptr.1210
M3 - Artículo
SN - 0951-418X
VL - 17
SP - 618
EP - 619
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 6
ER -