TY - JOUR
T1 - Anti-obesity effect of cocoa proteins (Theobroma cacao L.) variety “Criollo” and the expression of genes related to the dysfunction of white adipose tissue in high-fat diet-induced obese rats
AU - Coronado-Cáceres, Luis Jorge
AU - Rabadán-Chávez, Griselda
AU - Quevedo-Corona, Lucía
AU - Hernández-Ledesma, Blanca
AU - Garcia, Angel Miliar
AU - Mojica, Luis
AU - Lugo-Cervantes, Eugenia
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/11
Y1 - 2019/11
N2 - The objective of this work was to evaluate if Cocoa Proteins (CP) from the cocoa-bean were able to reduce factors related to obesity and activated related gene targets against white adipose tissue (WAT) dysfunction in a rat model of hypercaloric diet-induced obesity. The results showed that the administration with 150 mg/kg/day of CP on a hypercaloric diet reduces body-weight gain, relative weight of WAT, serum triglycerides, NEFAs, insulin, and leptin levels, and pro-inflammatory factors, with an increase in serum HDL levels, activation (AMPK, PPAR-γ, PPAR-α, SIRT1, Plin1, and PGC-1α) and repression (TNF-α, SREBP-1c, Leptin and ACC) of the mRNA of transcription factors and proteins related to WAT dysfunction. The CP prevented dysfunction in WAT who is related to obesity by down-regulation of factors related to lipogenesis and up-regulation of those related to energy expenditure, lowering the release of triglycerides and NEFAs into peripheral tissues, thus decreasing pro-inflammatory processes.
AB - The objective of this work was to evaluate if Cocoa Proteins (CP) from the cocoa-bean were able to reduce factors related to obesity and activated related gene targets against white adipose tissue (WAT) dysfunction in a rat model of hypercaloric diet-induced obesity. The results showed that the administration with 150 mg/kg/day of CP on a hypercaloric diet reduces body-weight gain, relative weight of WAT, serum triglycerides, NEFAs, insulin, and leptin levels, and pro-inflammatory factors, with an increase in serum HDL levels, activation (AMPK, PPAR-γ, PPAR-α, SIRT1, Plin1, and PGC-1α) and repression (TNF-α, SREBP-1c, Leptin and ACC) of the mRNA of transcription factors and proteins related to WAT dysfunction. The CP prevented dysfunction in WAT who is related to obesity by down-regulation of factors related to lipogenesis and up-regulation of those related to energy expenditure, lowering the release of triglycerides and NEFAs into peripheral tissues, thus decreasing pro-inflammatory processes.
KW - Adipose tissue
KW - Anti-inflammatory
KW - Food protein
KW - Functional foods
KW - Gene expression
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85071640678&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2019.103519
DO - 10.1016/j.jff.2019.103519
M3 - Artículo
AN - SCOPUS:85071640678
SN - 1756-4646
VL - 62
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 103519
ER -