Anterior subdiaphragmatic vagotomy decreases the IgA antibody response in the small intestines of BALB/c mice

Ivonne Maciel Arciniega-Martínez, Maria Elisa Drago-Serrano, Marisol Salas-Pimentel, Javier Ventura-Juárez, Aldo Arturo Reséndiz-Albor, Rafael Campos-Rodríguez

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

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Resumen

To assess the impact of vagotomy on the IgA-response, male BALB/c mice underwent anterior vagotomy or a sham procedure were sacrificed on day 14 post-operation and the proximal and distal small-gut segments were dissected. In intestinal lavages IgA/IgM antibodies were analysed by ELISA; in Peyer's-patches and lamina-propria cell suspensions the intracellular IgA-associated interleukins (ILs) and pro-inflammatory cytokines in CD4+ T cells were analysed by cytofluorometry. Vagotomy reduced the IgA or increased the IgM antibody concentration in both segments and reduced or increased the lamina- propria CD4+ T cell pro-inflammatory cytokine responses in the distal or proximal segments, respectively. Data show the role of the vagus nerve on the IgA response.

Idioma originalInglés
Número de artículo577072
PublicaciónJournal of Neuroimmunology
Volumen337
DOI
EstadoPublicada - 15 dic. 2019

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