TY - JOUR
T1 - Angiotensin-converting enzyme inhibitors from Salvia elegans Vahl
AU - Gutiérrez-Román, Ana Silvia
AU - Gonzalez-Cortazar, Manasés
AU - Trejo-Tapia, Gabriela
AU - Herrera-Ruiz, Maribel
AU - Zamilpa, Alejandro
AU - Sanchéz-Mendoza, Ernesto
AU - De la Cruz- Sanchez, Natividad Giovana
AU - Jiménez-Ferrer, Enrique
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Phytochemical research of the acetate and methanol extracts of the aerial parts (flowers, leaves and stems) of Salvia elegans allowed to obtain seventeen known compounds (1–17): three of them (4, 5, 14), had already been described for this species, while the others (1–3, 6–13, 15–17) are described for the first time for S. elegans. All isolated compounds were characterized using spectroscopic techniques and mass spectrometry and were evaluated in the Angiotensin I-converting enzyme (ACE) inhibition model, where the phenolic compounds (13, 14 and 15) had the same inhibitory effect as lisinopril at 0.02 mg/mL. The terpenes showed a moderate inhibitory capacity at a concentration of 0.2 mg/mL.
AB - Phytochemical research of the acetate and methanol extracts of the aerial parts (flowers, leaves and stems) of Salvia elegans allowed to obtain seventeen known compounds (1–17): three of them (4, 5, 14), had already been described for this species, while the others (1–3, 6–13, 15–17) are described for the first time for S. elegans. All isolated compounds were characterized using spectroscopic techniques and mass spectrometry and were evaluated in the Angiotensin I-converting enzyme (ACE) inhibition model, where the phenolic compounds (13, 14 and 15) had the same inhibitory effect as lisinopril at 0.02 mg/mL. The terpenes showed a moderate inhibitory capacity at a concentration of 0.2 mg/mL.
KW - Angiotensin-converting enzyme inhibitor
KW - Salvia elegans Vahl
KW - phenolic compounds
KW - terpenes
UR - http://www.scopus.com/inward/record.url?scp=85084351562&partnerID=8YFLogxK
U2 - 10.1080/14786419.2020.1758093
DO - 10.1080/14786419.2020.1758093
M3 - Artículo
C2 - 32347111
SN - 1478-6419
VL - 35
SP - 5344
EP - 5349
JO - Natural Product Research
JF - Natural Product Research
IS - 23
ER -