Angiotensin Converting Enzyme 1 Polymorphisms and Lipid Profile in Mexican Patients With COVID-19

Evelyn Romero Mateos; Paola Zárate-Segura; Fernando Bastida-González; Maria Jose Perez Mendez; Eduardo Davila Gonzalez; Aaron Garduño Gutiérrez; Rosalva Sotelo Salas; Jose Juan Ceballos Macias; Horacio Sosa Corales; Francisco Lucio Monter Pascual; Guadalupe Cleva Villanueva López

doi:10.21873/invivo.13096

Angiotensin Converting Enzyme 1 Polymorphisms and Lipid Profile in Mexican Patients With COVID-19

Título traducido de la contribución: Polimorfismos de la enzima convertidora de angiotensina 1 y perfil lipìdico en pacientes mexicanos con COVID19

Evelyn Romero Mateos, Paola Zárate-Segura, Fernando Bastida-González, Maria Jose Perez Mendez, Eduardo Davila Gonzalez, Aaron Garduño Gutiérrez, Rosalva Sotelo Salas, Jose Juan Ceballos Macias, Horacio Sosa Corales, Francisco Lucio Monter Pascual, Guadalupe Cleva Villanueva López

Escuela Superior de Medicina (ESM)

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

Background/Aim: Renin-angiotensin system (RAS) is present in a diverse type of cells and plays an important role in lung physiology and pathophysiology.
Angiotensin converting enzymes (ACE) are part of the RAS system. There are still controversies about the association of I/D polymorphisms of ACE1 with COVID-19 severity. The goal of the study was to determine whether there is an
association of the I/D polymorphism with severity of COVID- 19 in Mexican patients. Patients and Methods: The study included voluntary participants: 53 healthy individuals negative to RT-PCR COVID-19 (control), and 165 patients
positive to COVID-19. Severity was defined by the need of hospitalization, invasive ventilation, shock, or multiple organ failure. The patient group consisted of 28 asymptomatic, 82 with mild, and 55 with severe COVID-19. I/D polymorphism was determined by PCR. Rutinary laboratory tests were performed in all the participants. Results: DD polymorphism was significantly associated with severe COVID-19, independently of comorbidities, or any other variable.
Receiver operator characteristic curves demonstrated association of low total cholesterol, low high-density lipoproteins, and high c-reactive protein with severity of COVID-19. Conclusion: The DD polymorphism was associated with the course of the infection and severity of COVID-19 in a sample of Mexican patients.

Título traducido de la contribución	Polimorfismos de la enzima convertidora de angiotensina 1 y perfil lipìdico en pacientes mexicanos con COVID19
Idioma original	Inglés
Número de artículo	1
Páginas (desde-hasta)	433-439
Número de páginas	7
Publicación	In Vivo
Volumen	37
DOI	https://doi.org/10.21873/invivo.13096
Estado	Publicada - 1 ene. 2023

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10.21873/invivo.13096Licencia: Otros

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Mateos, E. R., Zárate-Segura, P., Bastida-González, F., Perez Mendez, M. J., Davila Gonzalez, E., Garduño Gutiérrez, A., Sotelo Salas, R., Ceballos Macias, J. J., Sosa Corales, H., Lucio Monter Pascual, F., & Villanueva López, G. C. (2023). Angiotensin Converting Enzyme 1 Polymorphisms and Lipid Profile in Mexican Patients With COVID-19. In Vivo, 37, 433-439. [1]. https://doi.org/10.21873/invivo.13096

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title = "Angiotensin Converting Enzyme 1 Polymorphisms and Lipid Profile in Mexican Patients With COVID-19",

abstract = "Background/Aim: Renin-angiotensin system (RAS) is present in a diverse type of cells and plays an important role in lung physiology and pathophysiology.Angiotensin converting enzymes (ACE) are part of the RAS system. There are still controversies about the association of I/D polymorphisms of ACE1 with COVID-19 severity. The goal of the study was to determine whether there is anassociation of the I/D polymorphism with severity of COVID- 19 in Mexican patients. Patients and Methods: The study included voluntary participants: 53 healthy individuals negative to RT-PCR COVID-19 (control), and 165 patientspositive to COVID-19. Severity was defined by the need of hospitalization, invasive ventilation, shock, or multiple organ failure. The patient group consisted of 28 asymptomatic, 82 with mild, and 55 with severe COVID-19. I/D polymorphism was determined by PCR. Rutinary laboratory tests were performed in all the participants. Results: DD polymorphism was significantly associated with severe COVID-19, independently of comorbidities, or any other variable.Receiver operator characteristic curves demonstrated association of low total cholesterol, low high-density lipoproteins, and high c-reactive protein with severity of COVID-19. Conclusion: The DD polymorphism was associated with the course of the infection and severity of COVID-19 in a sample of Mexican patients.",

author = "Mateos, {Evelyn Romero} and Paola Z{\'a}rate-Segura and Fernando Bastida-Gonz{\'a}lez and {Perez Mendez}, {Maria Jose} and {Davila Gonzalez}, Eduardo and {Gardu{\~n}o Guti{\'e}rrez}, Aaron and {Sotelo Salas}, Rosalva and {Ceballos Macias}, {Jose Juan} and {Sosa Corales}, Horacio and {Lucio Monter Pascual}, Francisco and {Villanueva L{\'o}pez}, {Guadalupe Cleva}",

year = "2023",

month = jan,

day = "1",

doi = "10.21873/invivo.13096",

language = "Ingl{\'e}s",

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pages = "433--439",

journal = "In Vivo",

issn = "0258-851X",

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Mateos, ER, Zárate-Segura, P, Bastida-González, F, Perez Mendez, MJ, Davila Gonzalez, E, Garduño Gutiérrez, A, Sotelo Salas, R, Ceballos Macias, JJ, Sosa Corales, H, Lucio Monter Pascual, F & Villanueva López, GC 2023, 'Angiotensin Converting Enzyme 1 Polymorphisms and Lipid Profile in Mexican Patients With COVID-19', In Vivo, vol. 37, 1, pp. 433-439. https://doi.org/10.21873/invivo.13096

TY - JOUR

T1 - Angiotensin Converting Enzyme 1 Polymorphisms and Lipid Profile in Mexican Patients With COVID-19

AU - Mateos, Evelyn Romero

AU - Zárate-Segura, Paola

AU - Bastida-González, Fernando

AU - Perez Mendez, Maria Jose

AU - Davila Gonzalez, Eduardo

AU - Garduño Gutiérrez, Aaron

AU - Sotelo Salas, Rosalva

AU - Ceballos Macias, Jose Juan

AU - Sosa Corales, Horacio

AU - Lucio Monter Pascual, Francisco

AU - Villanueva López, Guadalupe Cleva

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Background/Aim: Renin-angiotensin system (RAS) is present in a diverse type of cells and plays an important role in lung physiology and pathophysiology.Angiotensin converting enzymes (ACE) are part of the RAS system. There are still controversies about the association of I/D polymorphisms of ACE1 with COVID-19 severity. The goal of the study was to determine whether there is anassociation of the I/D polymorphism with severity of COVID- 19 in Mexican patients. Patients and Methods: The study included voluntary participants: 53 healthy individuals negative to RT-PCR COVID-19 (control), and 165 patientspositive to COVID-19. Severity was defined by the need of hospitalization, invasive ventilation, shock, or multiple organ failure. The patient group consisted of 28 asymptomatic, 82 with mild, and 55 with severe COVID-19. I/D polymorphism was determined by PCR. Rutinary laboratory tests were performed in all the participants. Results: DD polymorphism was significantly associated with severe COVID-19, independently of comorbidities, or any other variable.Receiver operator characteristic curves demonstrated association of low total cholesterol, low high-density lipoproteins, and high c-reactive protein with severity of COVID-19. Conclusion: The DD polymorphism was associated with the course of the infection and severity of COVID-19 in a sample of Mexican patients.

AB - Background/Aim: Renin-angiotensin system (RAS) is present in a diverse type of cells and plays an important role in lung physiology and pathophysiology.Angiotensin converting enzymes (ACE) are part of the RAS system. There are still controversies about the association of I/D polymorphisms of ACE1 with COVID-19 severity. The goal of the study was to determine whether there is anassociation of the I/D polymorphism with severity of COVID- 19 in Mexican patients. Patients and Methods: The study included voluntary participants: 53 healthy individuals negative to RT-PCR COVID-19 (control), and 165 patientspositive to COVID-19. Severity was defined by the need of hospitalization, invasive ventilation, shock, or multiple organ failure. The patient group consisted of 28 asymptomatic, 82 with mild, and 55 with severe COVID-19. I/D polymorphism was determined by PCR. Rutinary laboratory tests were performed in all the participants. Results: DD polymorphism was significantly associated with severe COVID-19, independently of comorbidities, or any other variable.Receiver operator characteristic curves demonstrated association of low total cholesterol, low high-density lipoproteins, and high c-reactive protein with severity of COVID-19. Conclusion: The DD polymorphism was associated with the course of the infection and severity of COVID-19 in a sample of Mexican patients.

U2 - 10.21873/invivo.13096

DO - 10.21873/invivo.13096

M3 - Artículo

C2 - 36593047

SN - 0258-851X

VL - 37

SP - 433

EP - 439

JO - In Vivo

JF - In Vivo

M1 - 1

ER -