TY - JOUR
T1 - An efficient synthesis of aziridines from ephedrines
AU - Cruz, Alejandro
AU - Padilla-Martínez, Itzia Irene
AU - García-Báez, Efrén V.
N1 - Funding Information:
Alejandro Cruz thanks Secretaría de Investigación y Posgrado del IPN , Grant SIP-20080690 , for the financial support.
PY - 2010
Y1 - 2010
N2 - The reaction of chlorodeoxyephedrine hydrochlorides with one, two, and three molar equivalents of base was studied. Isochlorodeoxypseudoepherines were identified and assigned by 1H and 13C NMR data as intermediate compounds in the formation of cis-aziridines. Erythro and threo ephedrinethylethers were isolated as new compounds and analyzed by spectroscopic data. In addition, the erythro isomer was studied by X-ray diffraction.
AB - The reaction of chlorodeoxyephedrine hydrochlorides with one, two, and three molar equivalents of base was studied. Isochlorodeoxypseudoepherines were identified and assigned by 1H and 13C NMR data as intermediate compounds in the formation of cis-aziridines. Erythro and threo ephedrinethylethers were isolated as new compounds and analyzed by spectroscopic data. In addition, the erythro isomer was studied by X-ray diffraction.
UR - http://www.scopus.com/inward/record.url?scp=77954312402&partnerID=8YFLogxK
U2 - 10.1016/j.tetasy.2010.05.007
DO - 10.1016/j.tetasy.2010.05.007
M3 - Artículo
SN - 0957-4166
VL - 21
SP - 909
EP - 913
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 8
ER -