Enfermedad de Alzheimer: Una panorámica desde su primera descripción hacia una perspectiva molecular

Background: Alzheimer disease was described at beginning XX century by Alois Alzheimer, it represent the first cause of dementia at word. Its etiology is unknown, its genesis has genetics factors better knowing and environment factors not all unknowing. Objective: This review had purpose to made a bibliographic investigation about historic and vanguard molecular aspect of Alzheimer's disease. Methods: To Alzheimer's disease historic aspect review, we were made a search into Europe medicine history's books and Goggle searcher for internet. To molecular biology review we got in Medline and Ovid using key words: "molecular biology Alzheimer's disease", "fisiopathology Alzheimer's disease", "pathology Alzheimer's disease", "genetics Alzheimer's disease" from 1989 to 2009. We chose articles review, solid investigations and ladders' topics investigators. Results: from more 10,770 articles found, we choose forty nine whose had got criteria. Conclusions: The angular stone pathogenesis in this disease is A-beta amyloid protein deposit following a cascade intra and extra neuronal events at top death cellular.