TY - JOUR
T1 - Advances in heterocycles as DNA intercalating cancer drugs
AU - Das, Aparna
AU - Banik, Bimal Krishna
N1 - Publisher Copyright:
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - The insertion of a molecule between the bases of DNA is known as intercalation. A molecule is able to interact with DNA in different ways. DNA intercalators are generally aromatic, planar, and polycyclic. In chemotherapeutic treatment, to suppress DNA replication in cancer cells, intercalators are used. In this article, we discuss the anticancer activity of 10 intensively studied DNA intercalators as drugs. The list includes proflavine, ethidium bromide, doxorubicin, dactinomycin, bleomycin, epirubicin, mitoxantrone, ellipticine, elinafide, and echinomycin. Considerable structural diversities are seen in these molecules. Besides, some examples of the metallo-intercalators are presented at the end of the chapter. These molecules have other crucial properties that are also useful in the treatment of cancers. The successes and limitations of these molecules are also presented.
AB - The insertion of a molecule between the bases of DNA is known as intercalation. A molecule is able to interact with DNA in different ways. DNA intercalators are generally aromatic, planar, and polycyclic. In chemotherapeutic treatment, to suppress DNA replication in cancer cells, intercalators are used. In this article, we discuss the anticancer activity of 10 intensively studied DNA intercalators as drugs. The list includes proflavine, ethidium bromide, doxorubicin, dactinomycin, bleomycin, epirubicin, mitoxantrone, ellipticine, elinafide, and echinomycin. Considerable structural diversities are seen in these molecules. Besides, some examples of the metallo-intercalators are presented at the end of the chapter. These molecules have other crucial properties that are also useful in the treatment of cancers. The successes and limitations of these molecules are also presented.
KW - DNA intercalators
KW - anticancer drugs
KW - biological activity
KW - heterocycles
UR - http://www.scopus.com/inward/record.url?scp=85122640491&partnerID=8YFLogxK
U2 - 10.1515/psr-2021-0065
DO - 10.1515/psr-2021-0065
M3 - Artículo
AN - SCOPUS:85122640491
SN - 2365-659X
VL - 8
SP - 2473
EP - 2521
JO - Physical Sciences Reviews
JF - Physical Sciences Reviews
IS - 9
ER -