Advances in heterocycles as DNA intercalating cancer drugs

Aparna Das, Bimal Krishna Banik

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

The insertion of a molecule between the bases of DNA is known as intercalation. A molecule is able to interact with DNA in different ways. DNA intercalators are generally aromatic, planar, and polycyclic. In chemotherapeutic treatment, to suppress DNA replication in cancer cells, intercalators are used. In this article, we discuss the anticancer activity of 10 intensively studied DNA intercalators as drugs. The list includes proflavine, ethidium bromide, doxorubicin, dactinomycin, bleomycin, epirubicin, mitoxantrone, ellipticine, elinafide, and echinomycin. Considerable structural diversities are seen in these molecules. Besides, some examples of the metallo-intercalators are presented at the end of the chapter. These molecules have other crucial properties that are also useful in the treatment of cancers. The successes and limitations of these molecules are also presented.

Idioma originalInglés
PublicaciónPhysical Sciences Reviews
DOI
EstadoAceptada/en prensa - 2022
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Advances in heterocycles as DNA intercalating cancer drugs'. En conjunto forman una huella única.

Citar esto