TY - JOUR
T1 - Actividad antimicobacteriana y antiprotozoaria de Moussonia deppeana (Schldl and Cham) Hanst
AU - Jiménez-Arellanes, María Adelina
AU - Yépez-Mulia, Lilián
AU - Luna-Herrera, Julieta
AU - Gutiérrez-Rebolledo, Gabriel Alfonso
AU - García-Rodríguez, Rosa Virginia
PY - 2013
Y1 - 2013
N2 - Moussonia deppeana is known as tlachichinole, clachichinole, etc. In Mexican traditional medicine is used to treat gastrointestinal disorders, cough, stomach and duodenal ulcers, kidney and vaginal infections. The organic extracts prepared by maceration were evaluated against 11 mycobacterial strains and three protozoal. The AcOEt extract was active against Mycobacterium tuberculosis H37Rv, etambutol-resistant of H37Rv, and the clinical isolate SIN4 showed MIC=12.5 μg/mL, and against MMDO showed an MIC = 25 μg/mL. The Hex extract resulted moderately active against ethambutol-resistant of H37Rv and clinical isolates SIN4 and MMDO (MIC = 25 μg/mL). The Hex, AcOEt, and EtOH extracts were inactive against non-tuberculous mycobacterium strains showed MIC >50 μg/mL and against Giardia lamblia, Entamoeba histolytica, and Trichomona vaginalis showed IC50 >200 μg/mL. M. deppeana biosynthesized compounds with antimycobacterial activity.
AB - Moussonia deppeana is known as tlachichinole, clachichinole, etc. In Mexican traditional medicine is used to treat gastrointestinal disorders, cough, stomach and duodenal ulcers, kidney and vaginal infections. The organic extracts prepared by maceration were evaluated against 11 mycobacterial strains and three protozoal. The AcOEt extract was active against Mycobacterium tuberculosis H37Rv, etambutol-resistant of H37Rv, and the clinical isolate SIN4 showed MIC=12.5 μg/mL, and against MMDO showed an MIC = 25 μg/mL. The Hex extract resulted moderately active against ethambutol-resistant of H37Rv and clinical isolates SIN4 and MMDO (MIC = 25 μg/mL). The Hex, AcOEt, and EtOH extracts were inactive against non-tuberculous mycobacterium strains showed MIC >50 μg/mL and against Giardia lamblia, Entamoeba histolytica, and Trichomona vaginalis showed IC50 >200 μg/mL. M. deppeana biosynthesized compounds with antimycobacterial activity.
KW - Antiprotozoal activity
KW - Medicinal plant
KW - Moussonia deppeana
KW - Mycobacterium tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84902778992&partnerID=8YFLogxK
M3 - Artículo
SN - 1027-3956
VL - 44
SP - 31
EP - 35
JO - Revista Mexicana de Ciencias Farmaceuticas
JF - Revista Mexicana de Ciencias Farmaceuticas
IS - 2
ER -