TY - JOUR
T1 - Anti-hyperglycemic activity of aqueous extracts of cells produced in Ibervillea sonorae (S. Watson) Green cell culture on murine model
AU - Gómez-Guzmán, Alonso
AU - Ramírez-Sotelo, María Guadalupe
AU - Oliver-Salvador, María Del Carmen
AU - García-Salas, Sergio
AU - Cornejo-Garrido, Jorge
AU - Ordaz-Pichardo, Cynthia
N1 - Publisher Copyright:
© 2023, MS-Editions. All rights reserved.
PY - 2023/1
Y1 - 2023/1
N2 - Ibervillea sonorae (S. Watson) Greene, is a plant native to Mexico, where its roots have been used traditionally for treating Diabetes Mellitus. The aim of this work was to establishment of cell cultures of stem explants of I. sonorae and evaluation of the anti-hyperglycemic activity of cell aqueous extract on a murine model of streptozotocin-induced diabetic rats. Cell extracts had 2.29 mg palmitic acid/g extracted, and other compounds with pharmacological activities like palmitoyl ethanolamide and palmitoyl tryptamine were also identified. Diabetic rats treated with aqueous cell extract decreased glucose levels from 350 mg/dL to 145 mg/dL, AST and ALT from 164 U/L to 49 U/L and 99 U/L to 53 U/L, respectively. Additionally, there were no changes in the cellular morphology of the pancreas, liver, kidneys, and spleen. These results revealed that the cell aqueous extract from stem explants has anti-hyperglycemic activity.
AB - Ibervillea sonorae (S. Watson) Greene, is a plant native to Mexico, where its roots have been used traditionally for treating Diabetes Mellitus. The aim of this work was to establishment of cell cultures of stem explants of I. sonorae and evaluation of the anti-hyperglycemic activity of cell aqueous extract on a murine model of streptozotocin-induced diabetic rats. Cell extracts had 2.29 mg palmitic acid/g extracted, and other compounds with pharmacological activities like palmitoyl ethanolamide and palmitoyl tryptamine were also identified. Diabetic rats treated with aqueous cell extract decreased glucose levels from 350 mg/dL to 145 mg/dL, AST and ALT from 164 U/L to 49 U/L and 99 U/L to 53 U/L, respectively. Additionally, there were no changes in the cellular morphology of the pancreas, liver, kidneys, and spleen. These results revealed that the cell aqueous extract from stem explants has anti-hyperglycemic activity.
KW - Anti-hyperglycemic activity
KW - Cell cultures
KW - Diabetes Mellitus
KW - Ibervillea sonorae
KW - Secondary metabolites
UR - http://www.scopus.com/inward/record.url?scp=85137550335&partnerID=8YFLogxK
U2 - 10.37360/blacpma.23.22.1.6
DO - 10.37360/blacpma.23.22.1.6
M3 - Artículo
AN - SCOPUS:85137550335
SN - 0717-7917
VL - 22
SP - 68
EP - 85
JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
JF - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
IS - 1
ER -