Acetonic and methanolic extracts of heterotheca inuloides, and quercetin, decrease CCloxidative stress in several rat tissues

Elvia Coballase-Urrutia, José Pedraza-Chaverri, Noemí Cárdenas-Rodríguez, Bernardino Huerta-Gertrudis, Mercedes Edna García-Cruz, Hortencia Montesinos-Correa, Dolores Javier Sánchez-González, Rafael Camacho-Carranza, Jesús Javier Espinosa-Aguirre

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Resumen

The present study was designed to test the hypothesis that the acetonic and methanolic extracts of H. inuloides prevent carbon tetrachloride-(CCl induced oxidative stress in vital tissues. Pretreatment with both H. inuloides extracts or quercetin attenuated the increase in serum activity of alkaline phosphatase (ALP), total bilirubin (BB), creatinine (CRE), and creatine kinase (CK), and impeded the decrease of γ-globulin (γ-GLOB) and albumin (ALB) observed in CClinduced tissue injury. The protective effect was confirmed by histological analysis with hematoxylin-eosin and periodic acid/Schiff's reagent. Level of lipid peroxidation was higher in the organs of rats exposed to CClthan in those of the animals treated with Heterohteca extracts or quercetin, and these showed levels similar to the untreated group. Pretreatment of animals with either of the extracts or quercetin also prevented the increase of 4-hydroxynonenal and 3-nitrotyrosine. Pretreatment with the plant extracts or quercetin attenuated CCltoxic effects on the activity of several antioxidant enzymes. The present results strongly suggest that the chemopreventive effect of the extracts used and quercetin, against CCltoxicity, is associated with their antioxidant properties and corroborated previous results obtained in liver tissue.

Idioma originalInglés
Número de artículo659165
PublicaciónEvidence-based Complementary and Alternative Medicine
Volumen2013
DOI
EstadoPublicada - 2013
Publicado de forma externa

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