A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model

Xelha Araujo-Padilla; María Guadalupe Delgado-López; Carlos Beltrán-Ortega; Eva Ramón-Gallegos

doi:10.1063/1.5095904

A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model

Xelha Araujo-Padilla, María Guadalupe Delgado-López, Carlos Beltrán-Ortega, Eva Ramón-Gallegos

Escuela Nacional de Ciencias Biológicas (ENCB)

Producción científica: Capítulo del libro/informe/acta de congreso › Contribución a la conferencia › revisión exhaustiva

Resumen

Photodynamic therapy (PDT) is a new technique that has already been applied to several types of cancer, which combines a photosensitizer, light and oxygen. Interstitial PDT is based on intra-tumor light delivery using laser fibers inserted via needle. In this work, the fiber TF-N09 and the high-power laser system BIOSPEC® were tested in a syngeneic breast cancer mouse model. Results obtained in this work indicates that the irradiation causes necrosis in both groups, a group treated with pre-photosensitizer and a non-treated group. Also, the maximum potency usable with this device was 500mW, since at a higher power the needle reached temperatures above 37 °C.

Idioma original	Inglés
Título de la publicación alojada	XV Mexican Symposium on Medical Physics
Editores	Carlos-Gerardo Trevino-Palacios, Karla-Paola Garcia-Pelagio, Olga-Leticia Avila-Aguirre, Ruben Fossion, Maria-Ester Brandan, Mariana Hernandez-Bojorquez
Editorial	American Institute of Physics Inc.
ISBN (versión digital)	9780735418202
DOI	https://doi.org/10.1063/1.5095904
Estado	Publicada - 10 abr. 2019
Evento	15th Mexican Symposium on Medical Physics - Mexico City, México Duración: 13 jun. 2018 → 15 jun. 2018

Serie de la publicación

Nombre	AIP Conference Proceedings
Volumen	2090
ISSN (versión impresa)	0094-243X
ISSN (versión digital)	1551-7616

Conferencia

Conferencia	15th Mexican Symposium on Medical Physics
País/Territorio	México
Ciudad	Mexico City
Período	13/06/18 → 15/06/18

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Araujo-Padilla, X., Delgado-López, M. G., Beltrán-Ortega, C., & Ramón-Gallegos, E. (2019). A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model. En C.-G. Trevino-Palacios, K.-P. Garcia-Pelagio, O.-L. Avila-Aguirre, R. Fossion, M.-E. Brandan, & M. Hernandez-Bojorquez (Eds.), XV Mexican Symposium on Medical Physics Artículo 040001 (AIP Conference Proceedings; Vol. 2090). American Institute of Physics Inc.. https://doi.org/10.1063/1.5095904

Araujo-Padilla, Xelha ; Delgado-López, María Guadalupe ; Beltrán-Ortega, Carlos et al. / A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model. XV Mexican Symposium on Medical Physics. editor / Carlos-Gerardo Trevino-Palacios ; Karla-Paola Garcia-Pelagio ; Olga-Leticia Avila-Aguirre ; Ruben Fossion ; Maria-Ester Brandan ; Mariana Hernandez-Bojorquez. American Institute of Physics Inc., 2019. (AIP Conference Proceedings).

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title = "A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec{\textregistered} in a syngeneic breast cancer model",

abstract = "Photodynamic therapy (PDT) is a new technique that has already been applied to several types of cancer, which combines a photosensitizer, light and oxygen. Interstitial PDT is based on intra-tumor light delivery using laser fibers inserted via needle. In this work, the fiber TF-N09 and the high-power laser system BIOSPEC{\textregistered} were tested in a syngeneic breast cancer mouse model. Results obtained in this work indicates that the irradiation causes necrosis in both groups, a group treated with pre-photosensitizer and a non-treated group. Also, the maximum potency usable with this device was 500mW, since at a higher power the needle reached temperatures above 37 °C.",

author = "Xelha Araujo-Padilla and Delgado-L{\'o}pez, {Mar{\'i}a Guadalupe} and Carlos Beltr{\'a}n-Ortega and Eva Ram{\'o}n-Gallegos",

note = "Publisher Copyright: {\textcopyright} 2019 Author(s).; 15th Mexican Symposium on Medical Physics ; Conference date: 13-06-2018 Through 15-06-2018",

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Araujo-Padilla, X, Delgado-López, MG, Beltrán-Ortega, C & Ramón-Gallegos, E 2019, A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model. En C-G Trevino-Palacios, K-P Garcia-Pelagio, O-L Avila-Aguirre, R Fossion, M-E Brandan & M Hernandez-Bojorquez (eds.), XV Mexican Symposium on Medical Physics., 040001, AIP Conference Proceedings, vol. 2090, American Institute of Physics Inc., 15th Mexican Symposium on Medical Physics, Mexico City, México, 13/06/18. https://doi.org/10.1063/1.5095904

A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model. / Araujo-Padilla, Xelha; Delgado-López, María Guadalupe; Beltrán-Ortega, Carlos et al.
XV Mexican Symposium on Medical Physics. ed. / Carlos-Gerardo Trevino-Palacios; Karla-Paola Garcia-Pelagio; Olga-Leticia Avila-Aguirre; Ruben Fossion; Maria-Ester Brandan; Mariana Hernandez-Bojorquez. American Institute of Physics Inc., 2019. 040001 (AIP Conference Proceedings; Vol. 2090).

Producción científica: Capítulo del libro/informe/acta de congreso › Contribución a la conferencia › revisión exhaustiva

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AU - Delgado-López, María Guadalupe

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AU - Ramón-Gallegos, Eva

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N2 - Photodynamic therapy (PDT) is a new technique that has already been applied to several types of cancer, which combines a photosensitizer, light and oxygen. Interstitial PDT is based on intra-tumor light delivery using laser fibers inserted via needle. In this work, the fiber TF-N09 and the high-power laser system BIOSPEC® were tested in a syngeneic breast cancer mouse model. Results obtained in this work indicates that the irradiation causes necrosis in both groups, a group treated with pre-photosensitizer and a non-treated group. Also, the maximum potency usable with this device was 500mW, since at a higher power the needle reached temperatures above 37 °C.

AB - Photodynamic therapy (PDT) is a new technique that has already been applied to several types of cancer, which combines a photosensitizer, light and oxygen. Interstitial PDT is based on intra-tumor light delivery using laser fibers inserted via needle. In this work, the fiber TF-N09 and the high-power laser system BIOSPEC® were tested in a syngeneic breast cancer mouse model. Results obtained in this work indicates that the irradiation causes necrosis in both groups, a group treated with pre-photosensitizer and a non-treated group. Also, the maximum potency usable with this device was 500mW, since at a higher power the needle reached temperatures above 37 °C.

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Araujo-Padilla X, Delgado-López MG, Beltrán-Ortega C, Ramón-Gallegos E. A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model. En Trevino-Palacios CG, Garcia-Pelagio KP, Avila-Aguirre OL, Fossion R, Brandan ME, Hernandez-Bojorquez M, editores, XV Mexican Symposium on Medical Physics. American Institute of Physics Inc. 2019. 040001. (AIP Conference Proceedings). doi: 10.1063/1.5095904

A pilot assay of interstitial photodynamic therapy with high-power laser system BioSpec® in a syngeneic breast cancer model

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