TY - JOUR
T1 - 2-aminoethyldiphenyl borinate
T2 - A multitarget compound with potential as a drug precursor
AU - Rosalez, Melvin N.
AU - Estevez-Fregoso, Elizabeth
AU - Alatorre, Alberto
AU - Abad-García, Antonio
AU - Soriano-Ursúa, Marvin A.
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Background: Boron is considered a trace element that induces various effects in systems of the human body. However, each boron-containing compound exerts different effects. Objective: To review the effects of 2-Aminoethyldiphenyl borinate (2-APB), an organoboron compound, on the human body, but also, its effects in animal models of human disease. 9 Methods: In this review, the information to showcase the expansion of these reported effects through interactions with several ion channels and other receptors has been reported. These effects are relevant in the biomedical and chemical fields due to the application of the reported data in developing therapeutic tools to modulate the functions of the immune, cardiovascular, gastrointestinal and nervous systems. Results: Accordingly, 2-APB acts as a modulator of adaptive and innate immunity, including the production of cytokines and the migration of leukocytes. Additionally, reports show that 2-APB exerts effects on neurons, smooth muscle cells and cardiomyocytes, and it provides a cytoprotective effect by the modulation and attenuation of reactive oxygen species. Conclusion: The molecular pharmacology of 2-APB supports both its potential to act as a drug and the desirable inclusion of its moieties in new drug development. Research evaluating its efficacy in treating pain and specific maladies, such as immune, cardiovascular, gastrointestinal and neurodegenerative disorders, is scarce but interesting.
AB - Background: Boron is considered a trace element that induces various effects in systems of the human body. However, each boron-containing compound exerts different effects. Objective: To review the effects of 2-Aminoethyldiphenyl borinate (2-APB), an organoboron compound, on the human body, but also, its effects in animal models of human disease. 9 Methods: In this review, the information to showcase the expansion of these reported effects through interactions with several ion channels and other receptors has been reported. These effects are relevant in the biomedical and chemical fields due to the application of the reported data in developing therapeutic tools to modulate the functions of the immune, cardiovascular, gastrointestinal and nervous systems. Results: Accordingly, 2-APB acts as a modulator of adaptive and innate immunity, including the production of cytokines and the migration of leukocytes. Additionally, reports show that 2-APB exerts effects on neurons, smooth muscle cells and cardiomyocytes, and it provides a cytoprotective effect by the modulation and attenuation of reactive oxygen species. Conclusion: The molecular pharmacology of 2-APB supports both its potential to act as a drug and the desirable inclusion of its moieties in new drug development. Research evaluating its efficacy in treating pain and specific maladies, such as immune, cardiovascular, gastrointestinal and neurodegenerative disorders, is scarce but interesting.
KW - 2-aminoethyldiphenyl borinate
KW - Calcium channels
KW - Cardiovascular system
KW - Immune system
KW - Nervous system
UR - http://www.scopus.com/inward/record.url?scp=85078379654&partnerID=8YFLogxK
U2 - 10.2174/1874467212666191025145429
DO - 10.2174/1874467212666191025145429
M3 - Artículo de revisión
C2 - 31654521
AN - SCOPUS:85078379654
SN - 1874-4672
VL - 13
SP - 57
EP - 75
JO - Current Molecular Pharmacology
JF - Current Molecular Pharmacology
IS - 1
ER -