TY - JOUR
T1 - (17) Effects of succinic acid derivatives on ex vivo acetylcholinesterase activity
AU - Raya, J. Espinosa
AU - Correa-Basurto, J.
AU - Alcántara, J. I.Vázquez
AU - Trujillo-Ferrara, J. G.
PY - 2005/12/15
Y1 - 2005/12/15
N2 - In the present study the acetylcholinesterase (AChE) inhibition and acute toxicity of two succinic acid derivatives were compared with tacrine. Administration of a single dose of each of two succinic acid derivatives produced a time and dose-dependent inhibition of brain AChE activity. Although the magnitude of the cholinergic effects observed with the two succinic acid derivatives was similar to that seen with tacrine and other AChE inhibitors, the toxicity study showed that the new inhibitors have less adverse side effects.
AB - In the present study the acetylcholinesterase (AChE) inhibition and acute toxicity of two succinic acid derivatives were compared with tacrine. Administration of a single dose of each of two succinic acid derivatives produced a time and dose-dependent inhibition of brain AChE activity. Although the magnitude of the cholinergic effects observed with the two succinic acid derivatives was similar to that seen with tacrine and other AChE inhibitors, the toxicity study showed that the new inhibitors have less adverse side effects.
UR - http://www.scopus.com/inward/record.url?scp=28744444847&partnerID=8YFLogxK
U2 - 10.1016/j.cbi.2005.10.062
DO - 10.1016/j.cbi.2005.10.062
M3 - Artículo
C2 - 16429502
AN - SCOPUS:28744444847
SN - 0009-2797
VL - 157-158
SP - 379
EP - 380
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
ER -