(17) Effects of succinic acid derivatives on ex vivo acetylcholinesterase activity

Resultado de la investigación: Contribución a una conferenciaArtículo

3 Citas (Scopus)

Resumen

In the present study the acetylcholinesterase (AChE) inhibition and acute toxicity of two succinic acid derivatives were compared with tacrine. Administration of a single dose of each of two succinic acid derivatives produced a time and dose-dependent inhibition of brain AChE activity. Although the magnitude of the cholinergic effects observed with the two succinic acid derivatives was similar to that seen with tacrine and other AChE inhibitors, the toxicity study showed that the new inhibitors have less adverse side effects.
Idioma originalInglés estadounidense
Páginas379-380
Número de páginas340
DOI
EstadoPublicada - 15 dic 2005
EventoChemico-Biological Interactions -
Duración: 15 dic 2005 → …

Conferencia

ConferenciaChemico-Biological Interactions
Período15/12/05 → …

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