α-Glucosidase and α-amylase inhibition potentials of ten wild Mexican species of Verbenaceae

José A. Ávila-Reyes, Norma Almaraz-Abarca, Eli A.Delgado Alvarado, Rene Torres-Ricario, Néstor Naranjo-Jiménez, Marcela V. Gutierrez-Velazquez, Laura S. González-Valdez, José N. Uribe-Soto, Andres Vasavilbazo-Saucedo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Purpose: To evaluate the inhibitory activity of 10 wild Verbenaceae species from Mexico against α-glucosidase and α-amylase. Methods: Ethanol leaf extracts of 10 Verbenaceae species from Mexico were prepared. The inhibitory activity of the extracts against α-glucosidase and α-amylase was evaluated using enzymatic protocols. At least four serial diluted concentrations of each extract was used to calculate the half-maximal inhibitory concentration (IC 50 ). Results: The 10 evaluated Verbenaceae species showed high α-glucosidase inhibition activity, but a low inhibitory effect on α-amylase. Aloysia gratissima (IC 50 = 0.122 mg/mL), Verbena carolina (IC 50 = 0.112 mg/mL), Bouchea prismatica (IC 50 = 0.122 mg/mL), Verbena menthiflora (IC 50 = 0.071mg/mL) and Priva mexicana (IC 50 = 0.032 mg/mL) exhibited the strongest inhibitory activities against α-glucosidase. Conclusion: All the Verbenaceae species studied possess α-glucosidase inhibitory effect, with P. mexicana being the one with the strongest activity. These findings demonstrate the highs potential of these species as a source of natural antihyperglycemic agents for type 2 diabetes therapy.

Idioma originalInglés
Páginas (desde-hasta)31-36
Número de páginas6
PublicaciónTropical Journal of Pharmaceutical Research
Volumen18
N.º1
DOI
EstadoPublicada - 1 ene 2019

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