TY - JOUR
T1 - Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm
AU - Hernandez-Delgadillo, Rene
AU - Velasco-Arias, Donaji
AU - Diaz, David
AU - Arevalo-Niño, Katiushka
AU - Garza-Enriquez, Marianela
AU - De la Garza-Ramos, Myriam A.
AU - Cabral-Romero, Claudio
PY - 2012
Y1 - 2012
N2 - Despite continuous efforts, the increasing prevalence of resistance among pathogenic bacteria to common antibiotics has become one of the most significant concerns in modern medicine. Nanostructured materials are used in many fields, including biological sciences and medicine. While some bismuth derivatives has been used in medicine to treat vomiting, nausea, diarrhea, and stomach pain, the biocidal activity of zerovalent bismuth nanoparticles has not yet been studied. The objective of this investigation was to analyze the antimicrobial activity of bismuth nanoparticles against oral bacteria and their antibiofilm capabilities. Results: Our results showed that stable colloidal bismuth nanoparticles had 69% antimicrobial activity against Streptococcus mutans growth and achieved complete inhibition of biofilm formation. These results are similar to those obtained with chlorhexidine, the most commonly used oral antiseptic agent. The minimal inhibitory concentration of bismuth nanoparticles that interfered with S. mutans growth was 0.5 mM. Conclusion: These results suggest that zerovalent bismuth nanoparticles could be an interesting antimicrobial agent to be incorporated into an oral antiseptic preparation.
AB - Despite continuous efforts, the increasing prevalence of resistance among pathogenic bacteria to common antibiotics has become one of the most significant concerns in modern medicine. Nanostructured materials are used in many fields, including biological sciences and medicine. While some bismuth derivatives has been used in medicine to treat vomiting, nausea, diarrhea, and stomach pain, the biocidal activity of zerovalent bismuth nanoparticles has not yet been studied. The objective of this investigation was to analyze the antimicrobial activity of bismuth nanoparticles against oral bacteria and their antibiofilm capabilities. Results: Our results showed that stable colloidal bismuth nanoparticles had 69% antimicrobial activity against Streptococcus mutans growth and achieved complete inhibition of biofilm formation. These results are similar to those obtained with chlorhexidine, the most commonly used oral antiseptic agent. The minimal inhibitory concentration of bismuth nanoparticles that interfered with S. mutans growth was 0.5 mM. Conclusion: These results suggest that zerovalent bismuth nanoparticles could be an interesting antimicrobial agent to be incorporated into an oral antiseptic preparation.
KW - Antimicrobial agent
KW - Biofilm
KW - Streptococcus mutans
KW - Zerovalent bismuth nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84863832883&partnerID=8YFLogxK
U2 - 10.2147/IJN.S29854
DO - 10.2147/IJN.S29854
M3 - Artículo
C2 - 22619547
AN - SCOPUS:84863832883
SN - 1176-9114
VL - 7
SP - 2109
EP - 2113
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
ER -