Vaginosis-associated bacteria and its association with HPV infection

Pablo Romero-Morelos, Cindy Bandala, Julián Jiménez-Tenorio, Mariana Valdespino-Zavala, Miriam Rodríguez-Esquivel, Reyna Anaid Gama-Ríos, Artfy Bandera, Mónica Mendoza-Rodríguez, Keiko Taniguchi, Daniel Marrero-Rodríguez, Ricardo López-Romero, Eva Ramón-Gallegos, Mauricio Salcedo

Research output: Contribution to journalArticle

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Abstract

© 2018 Elsevier España, S.L.U. Background and objective: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. Material and methods: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history. All samples were screened for Atopobium vaginae, Gardnerella vaginalis and HPV by PCR. Results: High HPV prevalence was found in precursor samples, and 30% of samples without lesions were positive for HPV. Virtually all samples contained sequences of both bacteria, and interestingly, there was not HPV association observed; these results could suggest that these microorganisms could be part of the cervical microbiome in Mexican population. Conclusions: The results obtained indicate that the bacteria analysed could be part of normal biome in Mexican women, suggesting a potential reconsideration of the pathogen role of these microorganisms.
Original languageAmerican English
Pages (from-to)1-5
Number of pages0
JournalMedicina Clinica
DOIs
StatePublished - 4 Jan 2019

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Papillomavirus Infections
Bacteria
Gardnerella vaginalis
Microbiota
Vagina
Uterine Cervical Neoplasms
Bacterial Vaginosis
Ecosystem
Neoplasms
Polymerase Chain Reaction
DNA
Health
Population

Cite this

Romero-Morelos, P., Bandala, C., Jiménez-Tenorio, J., Valdespino-Zavala, M., Rodríguez-Esquivel, M., Gama-Ríos, R. A., ... Salcedo, M. (2019). Vaginosis-associated bacteria and its association with HPV infection. Medicina Clinica, 1-5. https://doi.org/10.1016/j.medcli.2018.01.027
Romero-Morelos, Pablo ; Bandala, Cindy ; Jiménez-Tenorio, Julián ; Valdespino-Zavala, Mariana ; Rodríguez-Esquivel, Miriam ; Gama-Ríos, Reyna Anaid ; Bandera, Artfy ; Mendoza-Rodríguez, Mónica ; Taniguchi, Keiko ; Marrero-Rodríguez, Daniel ; López-Romero, Ricardo ; Ramón-Gallegos, Eva ; Salcedo, Mauricio. / Vaginosis-associated bacteria and its association with HPV infection. In: Medicina Clinica. 2019 ; pp. 1-5.
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abstract = "{\circledC} 2018 Elsevier Espa{\~n}a, S.L.U. Background and objective: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. Material and methods: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history. All samples were screened for Atopobium vaginae, Gardnerella vaginalis and HPV by PCR. Results: High HPV prevalence was found in precursor samples, and 30{\%} of samples without lesions were positive for HPV. Virtually all samples contained sequences of both bacteria, and interestingly, there was not HPV association observed; these results could suggest that these microorganisms could be part of the cervical microbiome in Mexican population. Conclusions: The results obtained indicate that the bacteria analysed could be part of normal biome in Mexican women, suggesting a potential reconsideration of the pathogen role of these microorganisms.",
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Romero-Morelos, P, Bandala, C, Jiménez-Tenorio, J, Valdespino-Zavala, M, Rodríguez-Esquivel, M, Gama-Ríos, RA, Bandera, A, Mendoza-Rodríguez, M, Taniguchi, K, Marrero-Rodríguez, D, López-Romero, R, Ramón-Gallegos, E & Salcedo, M 2019, 'Vaginosis-associated bacteria and its association with HPV infection', Medicina Clinica, pp. 1-5. https://doi.org/10.1016/j.medcli.2018.01.027

Vaginosis-associated bacteria and its association with HPV infection. / Romero-Morelos, Pablo; Bandala, Cindy; Jiménez-Tenorio, Julián; Valdespino-Zavala, Mariana; Rodríguez-Esquivel, Miriam; Gama-Ríos, Reyna Anaid; Bandera, Artfy; Mendoza-Rodríguez, Mónica; Taniguchi, Keiko; Marrero-Rodríguez, Daniel; López-Romero, Ricardo; Ramón-Gallegos, Eva; Salcedo, Mauricio.

In: Medicina Clinica, 04.01.2019, p. 1-5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vaginosis-associated bacteria and its association with HPV infection

AU - Romero-Morelos, Pablo

AU - Bandala, Cindy

AU - Jiménez-Tenorio, Julián

AU - Valdespino-Zavala, Mariana

AU - Rodríguez-Esquivel, Miriam

AU - Gama-Ríos, Reyna Anaid

AU - Bandera, Artfy

AU - Mendoza-Rodríguez, Mónica

AU - Taniguchi, Keiko

AU - Marrero-Rodríguez, Daniel

AU - López-Romero, Ricardo

AU - Ramón-Gallegos, Eva

AU - Salcedo, Mauricio

PY - 2019/1/4

Y1 - 2019/1/4

N2 - © 2018 Elsevier España, S.L.U. Background and objective: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. Material and methods: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history. All samples were screened for Atopobium vaginae, Gardnerella vaginalis and HPV by PCR. Results: High HPV prevalence was found in precursor samples, and 30% of samples without lesions were positive for HPV. Virtually all samples contained sequences of both bacteria, and interestingly, there was not HPV association observed; these results could suggest that these microorganisms could be part of the cervical microbiome in Mexican population. Conclusions: The results obtained indicate that the bacteria analysed could be part of normal biome in Mexican women, suggesting a potential reconsideration of the pathogen role of these microorganisms.

AB - © 2018 Elsevier España, S.L.U. Background and objective: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. Material and methods: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history. All samples were screened for Atopobium vaginae, Gardnerella vaginalis and HPV by PCR. Results: High HPV prevalence was found in precursor samples, and 30% of samples without lesions were positive for HPV. Virtually all samples contained sequences of both bacteria, and interestingly, there was not HPV association observed; these results could suggest that these microorganisms could be part of the cervical microbiome in Mexican population. Conclusions: The results obtained indicate that the bacteria analysed could be part of normal biome in Mexican women, suggesting a potential reconsideration of the pathogen role of these microorganisms.

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Romero-Morelos P, Bandala C, Jiménez-Tenorio J, Valdespino-Zavala M, Rodríguez-Esquivel M, Gama-Ríos RA et al. Vaginosis-associated bacteria and its association with HPV infection. Medicina Clinica. 2019 Jan 4;1-5. https://doi.org/10.1016/j.medcli.2018.01.027