TY - JOUR
T1 - V2 from a curtovirus is a suppressor of post-transcriptional gene silencing
AU - Luna, Ana P.
AU - Rodríguez-Negrete, Edgar A.
AU - Morilla, Gabriel
AU - Wang, Liping
AU - Lozano-Durán, Rosa
AU - Castillo, Araceli G.
AU - Bejarano, Eduardo R.
N1 - Publisher Copyright:
© 2017 The Authors.
PY - 2017/10
Y1 - 2017/10
N2 - The suppression of gene silencing is a key mechanism for the success of viral infection in plants. DNA viruses from the Geminiviridae family encode several proteins that suppress transcriptional and post-transcriptional gene silencing (TGS/ PTGS). In Begomovirus, the most abundant genus of this family, three out of six genome-encoded proteins, namely C2, C4 and V2, have been shown to suppress PTGS, with V2 being the strongest PTGS suppressor in transient assays. Beet curly top virus (BCTV), the model species for the Curtovirus genus, is able to infect the widest range of plants among geminiviruses. In this genus, only one protein, C2/L2, has been described as inhibiting PTGS. We show here that, despite the lack of sequence homology with its begomoviral counterpart, BCTV V2 acts as a potent PTGS suppressor, possibly by impairing the RDR6 (RNA-dependent RNA polymerase 6)/suppressor of gene silencing 3 (SGS3) pathway.
AB - The suppression of gene silencing is a key mechanism for the success of viral infection in plants. DNA viruses from the Geminiviridae family encode several proteins that suppress transcriptional and post-transcriptional gene silencing (TGS/ PTGS). In Begomovirus, the most abundant genus of this family, three out of six genome-encoded proteins, namely C2, C4 and V2, have been shown to suppress PTGS, with V2 being the strongest PTGS suppressor in transient assays. Beet curly top virus (BCTV), the model species for the Curtovirus genus, is able to infect the widest range of plants among geminiviruses. In this genus, only one protein, C2/L2, has been described as inhibiting PTGS. We show here that, despite the lack of sequence homology with its begomoviral counterpart, BCTV V2 acts as a potent PTGS suppressor, possibly by impairing the RDR6 (RNA-dependent RNA polymerase 6)/suppressor of gene silencing 3 (SGS3) pathway.
KW - BCTV
KW - Geminivirus
KW - RDR6
KW - RNA silencing
KW - Silencing suppressor
KW - V2
UR - http://www.scopus.com/inward/record.url?scp=85031036349&partnerID=8YFLogxK
U2 - 10.1099/jgv.0.000933
DO - 10.1099/jgv.0.000933
M3 - Artículo
C2 - 28933688
SN - 0022-1317
VL - 98
SP - 2607
EP - 2614
JO - Journal of General Virology
JF - Journal of General Virology
IS - 10
M1 - 000933
ER -