© 2019, Springer Nature Switzerland AG. Transgenic crops have been the recipient of strong support as well as vigorously opposed opinions since their appearance. In any case, their growth throughout the world has been remarkable, and the production and commercialization of transgenics in Latin America has been especially significant. The purpose of the present study was to analyze transgenic crop production trends around the world and the relationship between the area allocated to the cultivation of transgenic crops and the profits generated by this activity. Data concerning Latin American countries and their participation in transgenic crop production are addressed specifically. The present study used covariance analysis, Pearson’s correlation coefficient, time series analysis, Dicker–Fuller test, Durbin–Watson statistic, standardization, and different measures of central tendency. Results for the period between 1996 and 2016 show that, despite the significant increase in the area planted with this type of crops, their production presented a deterministic growth behavior, which is explained using a non-stationary model. Current data are insufficient to establish a causal relationship between cultivated hectares and their derived profits. Finally, the present study showed that production increased considerably from 2004 to 2016 in the cases of Brazil, Argentina, Paraguay, and Uruguay, as well as a positive relationship between the global area planted with transgenics and the corresponding area in these selected countries.