TY - JOUR
T1 - Evaluación toxicológica y farmacológica del extracto etanólico de las semillas de Swietenia humilis Zucc (caobilla)
AU - Rico-Rodriguez, Lilia
AU - Gómez-Flores, Delfina Esmeralda
AU - Ortiz-Butron, Rocío
AU - Cano-Europa, Edgar
AU - Franco-Colín, Margarita
N1 - Publisher Copyright:
© 2014, Asociacion Farmaceutica Mexicana A.C. All rights reserved.
PY - 2014
Y1 - 2014
N2 - The seeds of Swietenia humilis Zucc, traditionally consumed in many communities in the state of Sinaloa and other parts of the interior of Mexico for its healing properties in the treatment of different diseases like parasitosis, diarrhea, hyperglycemia and some conditions as overweight. Therefore the objective of this study was performed a pharmacological study of the ethanolic extract of the Swietenia humilis Zucc seeds. This study consisted in the determination of antinociceptive, and anticonvulsant activities of lethal dose 50 (LD50), in adults mice NIH. The in vitro spasmolytic effect and the antioxidant capacity were evaluated too. It was found that the LD50 was higher than 100 mg/Kg so their use is secure. With respect to the antinociceptive activity, all the administered doses reduce the number of contortions induced by acetic acid administration. The extract had not anticonvulsant activity and they did not show antioxidant activity, however it had spasmolytic activity. There were not else where reports about its spasmolytic and antinociceptive effects, therefore it is suggested to continue the evaluation of this extract to elucidate the structures responsible for these effects.
AB - The seeds of Swietenia humilis Zucc, traditionally consumed in many communities in the state of Sinaloa and other parts of the interior of Mexico for its healing properties in the treatment of different diseases like parasitosis, diarrhea, hyperglycemia and some conditions as overweight. Therefore the objective of this study was performed a pharmacological study of the ethanolic extract of the Swietenia humilis Zucc seeds. This study consisted in the determination of antinociceptive, and anticonvulsant activities of lethal dose 50 (LD50), in adults mice NIH. The in vitro spasmolytic effect and the antioxidant capacity were evaluated too. It was found that the LD50 was higher than 100 mg/Kg so their use is secure. With respect to the antinociceptive activity, all the administered doses reduce the number of contortions induced by acetic acid administration. The extract had not anticonvulsant activity and they did not show antioxidant activity, however it had spasmolytic activity. There were not else where reports about its spasmolytic and antinociceptive effects, therefore it is suggested to continue the evaluation of this extract to elucidate the structures responsible for these effects.
KW - Anticonvulsant
KW - Antinociceptive
KW - Letal dose 50
KW - Spasmolitic
KW - Swietenia humilis zucc
UR - http://www.scopus.com/inward/record.url?scp=84975468739&partnerID=8YFLogxK
M3 - Artículo
SN - 1027-3956
VL - 45
SP - 77
EP - 83
JO - Revista Mexicana de Ciencias Farmaceuticas
JF - Revista Mexicana de Ciencias Farmaceuticas
IS - 2
ER -