Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs

Silvia L. Cruz, Paulina Soberanes-Chávez, Nayeli Páez-Martinez, Carolina López-Rubalcava

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12 Citations (Scopus)

Abstract

Rationale: Many abused solvents share a profile of effects with classical antidepressants. For example, toluene, which is a representative and widely abused solvent, has been reported to increase both serotonin and noradrenaline levels in several brain areas after an acute exposure and to act as a noncompetitive antagonist of the glutamatergic N-methyl-d-aspartic acid (NMDA) receptor subtype. Therefore, it is possible that toluene could possess antidepressant-like actions. Objective: To provide an initial screening of toluene's antidepressant-like actions in the forced swimming test (FST) and the tail suspension test (TST) in mice and to analyze its possible mechanism of action. Materials and methods: Two series of experiments were performed. In the first one, male animals were exposed to toluene (0, 500, 1,000, 2,000, or 4,000 ppm) in a static exposure chamber for 30 min, and immediately after, evaluated for antidepressant-like effects. The results were compared with those obtained from mice treated with the serotonergic antidepressant clomipramine (CMI), the noradrenergic antidepressant desipramine (DMI), and the glutamatergic antidepressants, ketamine and MK-801. In the second part, we analyzed the effect of a combined administration of a subeffective concentration of toluene with a suboptimal dose of the various antidepressants acting at different neurotransmitter systems. Results: Toluene produced a concentration-dependent antidepressant-like action in the FST and TST and facilitated both MK-801 and ketamine antidepressant-like effects, but not those of DMI or CMI. Conclusions: Toluene has antidepressant-like effects that are synergized with NMDA receptor antagonists. © 2009 Springer-Verlag.
Original languageAmerican English
Pages (from-to)279-286
Number of pages250
JournalPsychopharmacology
DOIs
StatePublished - 1 Jun 2009

Fingerprint

Toluene
Antidepressive Agents
Animal Models
Hindlimb Suspension
Clomipramine
Desipramine
Dizocilpine Maleate
Ketamine
Neurotransmitter Agents
Serotonin
Norepinephrine

Cite this

Cruz, Silvia L. ; Soberanes-Chávez, Paulina ; Páez-Martinez, Nayeli ; López-Rubalcava, Carolina. / Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs. In: Psychopharmacology. 2009 ; pp. 279-286.
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abstract = "Rationale: Many abused solvents share a profile of effects with classical antidepressants. For example, toluene, which is a representative and widely abused solvent, has been reported to increase both serotonin and noradrenaline levels in several brain areas after an acute exposure and to act as a noncompetitive antagonist of the glutamatergic N-methyl-d-aspartic acid (NMDA) receptor subtype. Therefore, it is possible that toluene could possess antidepressant-like actions. Objective: To provide an initial screening of toluene's antidepressant-like actions in the forced swimming test (FST) and the tail suspension test (TST) in mice and to analyze its possible mechanism of action. Materials and methods: Two series of experiments were performed. In the first one, male animals were exposed to toluene (0, 500, 1,000, 2,000, or 4,000 ppm) in a static exposure chamber for 30 min, and immediately after, evaluated for antidepressant-like effects. The results were compared with those obtained from mice treated with the serotonergic antidepressant clomipramine (CMI), the noradrenergic antidepressant desipramine (DMI), and the glutamatergic antidepressants, ketamine and MK-801. In the second part, we analyzed the effect of a combined administration of a subeffective concentration of toluene with a suboptimal dose of the various antidepressants acting at different neurotransmitter systems. Results: Toluene produced a concentration-dependent antidepressant-like action in the FST and TST and facilitated both MK-801 and ketamine antidepressant-like effects, but not those of DMI or CMI. Conclusions: Toluene has antidepressant-like effects that are synergized with NMDA receptor antagonists. {\circledC} 2009 Springer-Verlag.",
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Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs. / Cruz, Silvia L.; Soberanes-Chávez, Paulina; Páez-Martinez, Nayeli; López-Rubalcava, Carolina.

In: Psychopharmacology, 01.06.2009, p. 279-286.

Research output: Contribution to journalArticleResearchpeer-review

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