Therapy guided by gastric impedance spectroscopy in a septic shock model in pigs

César A. González, Cleva Villanueva, Salah Othman, Emilio Sacristán

Research output: Contribution to conferencePaper

Abstract

The disruption of the gastric mucosa plays a key role in the evolution of shock and it is the "motor of multiple organ failure"; in this sense, no clinically useful method to directly monitor the level of mucosal ischemic injury is available yet to guide appropriate therapy for the critically ill. An experimental model was developed in order to demonstrate that resuscitation therapy by gastric impedance spectroscopy, using a minimally invasive gastric catheter, is feasible and therefore, to establish its potential as a practical future clinical monitoring tool for the critically ill. A septic shock model in pigs was developed, which reproduces the hemodynamic conditions of the critically ill patient. Intervention therapies were designed in order to promote changes in hemodynamic response as well as in splanchnic perfusion, conventionally guided and by impedance spectroscopy. At the end of experiments, survival in each intervention therapy was compared and the outcome was better in the therapy group guided by gastric electric impedance spectroscopy.
Original languageAmerican English
Pages2307-2310
Number of pages2075
StatePublished - 1 Dec 2004
EventAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings -
Duration: 1 Dec 2007 → …

Conference

ConferenceAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Period1/12/07 → …

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Dielectric Spectroscopy
Septic Shock
Stomach
Swine
Critical Illness
Hemodynamics
Viscera
Multiple Organ Failure
Therapeutics
Group Psychotherapy
Gastric Mucosa
Electric Impedance
Resuscitation
Shock
Theoretical Models
Catheters
Perfusion
Survival
Wounds and Injuries

Cite this

González, C. A., Villanueva, C., Othman, S., & Sacristán, E. (2004). Therapy guided by gastric impedance spectroscopy in a septic shock model in pigs. 2307-2310. Paper presented at Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, .
González, César A. ; Villanueva, Cleva ; Othman, Salah ; Sacristán, Emilio. / Therapy guided by gastric impedance spectroscopy in a septic shock model in pigs. Paper presented at Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, .2075 p.
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González, CA, Villanueva, C, Othman, S & Sacristán, E 2004, 'Therapy guided by gastric impedance spectroscopy in a septic shock model in pigs', Paper presented at Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 1/12/07 pp. 2307-2310.

Therapy guided by gastric impedance spectroscopy in a septic shock model in pigs. / González, César A.; Villanueva, Cleva; Othman, Salah; Sacristán, Emilio.

2004. 2307-2310 Paper presented at Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, .

Research output: Contribution to conferencePaper

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González CA, Villanueva C, Othman S, Sacristán E. Therapy guided by gastric impedance spectroscopy in a septic shock model in pigs. 2004. Paper presented at Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, .