TY - JOUR
T1 - The utility of the 13C-methacetin breath test in predicting the long-term survival of patients with decompensated cirrhosis
AU - Moran, Segundo
AU - Mina, Aline
AU - Duque, Ximena
AU - Ortiz-Olvera, Nayeli
AU - Rodriguez-Leal, Gustavo
AU - Alfredo Sierra-Ramírez, Jose
AU - Medina-Santillán, Roberto
AU - Mera, Robertino M.
AU - Uribe, Misael
N1 - Publisher Copyright:
© 2017 IOP Publishing Ltd.
PY - 2017/9/7
Y1 - 2017/9/7
N2 - Aim: The 13C-methacetin breath test (13C-MeBT) is a noninvasive tool that allows evaluation of the functional activity of the liver and the prediction of liver cirrhosis. Nevertheless, there is no information on its potential utility to predict long-term survival in patients with liver disease. Methods: Patients with cirrhosis were selected. All patients underwent a complete clinical assessment, standard biochemical tests, and 13C-MeBT at the beginning of the study. Death was recorded during the three years of follow-up. Survival curves were calculated by the Kaplan-Meier method, and Cox proportional risk models were used to identify predictive factors. The ability to classify the overall risk was assessed by the C statistic. Results: One hundred and twenty-three patients were included. A significant inverse correlation was found between delta over baseline at the 15 min point (DOB15) after ingestion of 13C-methacetin and the Child-Pugh score (r = -0.411, p < 0.001). In multivariate analysis, DOB15 ≤ 4.5‰ was associated with mortality, [HR = 2.58 95% CI (1.17-5.69)]. In conclusion, our results confirm the utility of 13C-MeBT as a simple, noninvasive tool to quantitatively assess the liver's functional reserve and as a potential predictor of long-term survival in patients with decompensated cirrhosis.
AB - Aim: The 13C-methacetin breath test (13C-MeBT) is a noninvasive tool that allows evaluation of the functional activity of the liver and the prediction of liver cirrhosis. Nevertheless, there is no information on its potential utility to predict long-term survival in patients with liver disease. Methods: Patients with cirrhosis were selected. All patients underwent a complete clinical assessment, standard biochemical tests, and 13C-MeBT at the beginning of the study. Death was recorded during the three years of follow-up. Survival curves were calculated by the Kaplan-Meier method, and Cox proportional risk models were used to identify predictive factors. The ability to classify the overall risk was assessed by the C statistic. Results: One hundred and twenty-three patients were included. A significant inverse correlation was found between delta over baseline at the 15 min point (DOB15) after ingestion of 13C-methacetin and the Child-Pugh score (r = -0.411, p < 0.001). In multivariate analysis, DOB15 ≤ 4.5‰ was associated with mortality, [HR = 2.58 95% CI (1.17-5.69)]. In conclusion, our results confirm the utility of 13C-MeBT as a simple, noninvasive tool to quantitatively assess the liver's functional reserve and as a potential predictor of long-term survival in patients with decompensated cirrhosis.
KW - C-methacetin breath test
KW - Child-Pugh score
KW - cirrhosis
KW - liver failure
UR - http://www.scopus.com/inward/record.url?scp=85029490339&partnerID=8YFLogxK
U2 - 10.1088/1752-7163/aa7b99
DO - 10.1088/1752-7163/aa7b99
M3 - Artículo
C2 - 28649974
SN - 1752-7155
VL - 11
JO - Journal of Breath Research
JF - Journal of Breath Research
IS - 3
M1 - 036011
ER -