The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos

S. García; G. Chavira-Hernández; M. P. Gallegos-Arreola; L. Dávila-Maldonado; F. García Martínez; L. A. Montes Almanza; C. Palma-Flores; P. Mondragón-Terán; S. L. Alcaraz Estrada; Luz Berenice López-Hernández

doi:10.1590/0004-282X20160061

The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos

Translated title of the contribution: The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos

S. García, G. Chavira-Hernández, M. P. Gallegos-Arreola, L. Dávila-Maldonado, F. García Martínez, L. A. Montes Almanza, C. Palma-Flores, P. Mondragón-Terán, S. L. Alcaraz Estrada, Luz Berenice López-Hernández

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Among the candidate genes for Parkinson’s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.

Translated title of the contribution	The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos
Original language	English
Pages (from-to)	445-449
Number of pages	5
Journal	Arquivos de Neuro-Psiquiatria
Volume	74
Issue number	6
DOIs	https://doi.org/10.1590/0004-282X20160061
State	Published - Jun 2016
Externally published	Yes

Keywords

Genes
Genetics
Parkinson disease
SNCA

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García, S., Chavira-Hernández, G., Gallegos-Arreola, M. P., Dávila-Maldonado, L., García Martínez, F., Montes Almanza, L. A., Palma-Flores, C., Mondragón-Terán, P., Alcaraz Estrada, S. L., & López-Hernández, L. B. (2016). The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos. Arquivos de Neuro-Psiquiatria, 74(6), 445-449. https://doi.org/10.1590/0004-282X20160061

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title = "The rs3857059 variant of the SNCA gene is associated with parkinson{\textquoteright}s disease in Mexican mestizos",

abstract = "Among the candidate genes for Parkinson{\textquoteright}s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.",

keywords = "Genes, Genetics, Parkinson disease, SNCA",

author = "S. Garc{\'i}a and G. Chavira-Hern{\'a}ndez and Gallegos-Arreola, {M. P.} and L. D{\'a}vila-Maldonado and {Garc{\'i}a Mart{\'i}nez}, F. and {Montes Almanza}, {L. A.} and C. Palma-Flores and P. Mondrag{\'o}n-Ter{\'a}n and {Alcaraz Estrada}, {S. L.} and L{\'o}pez-Hern{\'a}ndez, {Luz Berenice}",

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doi = "10.1590/0004-282X20160061",

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García, S, Chavira-Hernández, G, Gallegos-Arreola, MP, Dávila-Maldonado, L, García Martínez, F, Montes Almanza, LA, Palma-Flores, C, Mondragón-Terán, P, Alcaraz Estrada, SL & López-Hernández, LB 2016, 'The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos', Arquivos de Neuro-Psiquiatria, vol. 74, no. 6, pp. 445-449. https://doi.org/10.1590/0004-282X20160061

TY - JOUR

T1 - The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos

AU - García, S.

AU - Chavira-Hernández, G.

AU - Gallegos-Arreola, M. P.

AU - Dávila-Maldonado, L.

AU - García Martínez, F.

AU - Montes Almanza, L. A.

AU - Palma-Flores, C.

AU - Mondragón-Terán, P.

AU - Alcaraz Estrada, S. L.

AU - López-Hernández, Luz Berenice

PY - 2016/6

Y1 - 2016/6

N2 - Among the candidate genes for Parkinson’s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.

AB - Among the candidate genes for Parkinson’s disease (PD), SNCA has replicated association in different populations. Besides other known mutations in the SNCA gene, the rs3857059 variant has also been linked to various neurodegenerative disorders. Therefore, the aim of the present study was to search for association of this variant and sporadic PD in Mexican Mestizo patients. A case-control study was performed including 241 individuals, 106 patients, and 135 healthy controls. Genotyping was performed using real-time PCR. The rs3857059 variant demonstrated an association with PD in Mexican Mestizos (OR = 2.40, CI, 1.1 to 5.1, p = 0.02) under the recessive model. In addition, a gender effect was found for the GG genotype in females (OR = 1.31, CI, 1.01 to 1.7, p = 0.037). This is the first study to confirm an association of the rs3857059 variant with PD and also to show a gender effect. Our data contribute to the elucidation of the link between rs3857059 and susceptibility to PD observed in the Mexican Mestizo population.

KW - Genes

KW - Genetics

KW - Parkinson disease

KW - SNCA

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U2 - 10.1590/0004-282X20160061

DO - 10.1590/0004-282X20160061

M3 - Artículo

SN - 0004-282X

VL - 74

SP - 445

EP - 449

JO - Arquivos de Neuro-Psiquiatria

JF - Arquivos de Neuro-Psiquiatria

IS - 6

ER -

The rs3857059 variant of the SNCA gene is associated with parkinson’s disease in Mexican mestizos

Abstract

Keywords

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