The outer membrane vesicles: Secretion system type zero

Andrea Guerrero-Mandujano, Cecilia Hernández-Cortez, Jose Antonio Ibarra, Graciela Castro-Escarpulli

Research output: Contribution to journalScientific review

21 Scopus citations


© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Gram-negative bacteria have mechanisms through which they can colonize and survive in different environments, such as the secretion systems types (1-6) that have been widely studied and characterized. Nowadays, some authors have proposed extracellular structures, such as the outer membrane vesicles (OMVs), to be considered as an additional and independent secretion system. The OMVs are spherical particles of 50-250 nm in diameter; they originate in the outer membrane, and therefore they have a very similar composition to the latter. These particles can transport an important variety of biomolecules: enzymes, toxins, antigenic determinants and even nucleic acids. Thus, it is of great interest to collect data describing the advantages of the transport of biomolecules through the OMVs and, thus, determine their role as a potential secretion system.
Original languageAmerican English
Pages (from-to)425-432
Number of pages381
StatePublished - 1 Jul 2017


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