TY - JOUR
T1 - The liquisolid technique assisted with a cosolvent applied to a high dose drug-ibuprofen tablets
AU - Silva-Martínez, Gabriela B.
AU - Villafuerte Robles, Leopoldo
N1 - Publisher Copyright:
© 2018, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.
PY - 2018
Y1 - 2018
N2 - The objective was the investigation of the liquisolid technique, assisted with a cosolvent, in ibuprofen tablets. This study evaluates the hardness of the tablet, the disintegration time, the powder flow properties and the dissolution behavior. The obtained tablets disintegrate in less than 156 s, dissolving 68-98% ibuprofen in 10 min, while maintaining adequate hardness properties of the tablets and powder flow. The results are attributed to a cosolvent that allows a uniform distribution of the drug, partially dissolved in the non-volatile solvent, maximizing the exposure to the dissolution process, the disintegrant that facilitates the penetration of water and the solid used to “dry” the non-volatile solvent that leaves a granulate more or less “wet” and less fluid. The tablets obtained maintain in equilibrium a uniform distribution of the drug with sufficient disintegration and dissolution while maintaining a suitable hardness and flow properties of the powder.
AB - The objective was the investigation of the liquisolid technique, assisted with a cosolvent, in ibuprofen tablets. This study evaluates the hardness of the tablet, the disintegration time, the powder flow properties and the dissolution behavior. The obtained tablets disintegrate in less than 156 s, dissolving 68-98% ibuprofen in 10 min, while maintaining adequate hardness properties of the tablets and powder flow. The results are attributed to a cosolvent that allows a uniform distribution of the drug, partially dissolved in the non-volatile solvent, maximizing the exposure to the dissolution process, the disintegrant that facilitates the penetration of water and the solid used to “dry” the non-volatile solvent that leaves a granulate more or less “wet” and less fluid. The tablets obtained maintain in equilibrium a uniform distribution of the drug with sufficient disintegration and dissolution while maintaining a suitable hardness and flow properties of the powder.
KW - Compactibility
KW - Cosolvent
KW - Disintegration
KW - Dissolution
KW - Ibuprofen
KW - Liquisolid tablets
KW - Powder flow
UR - http://www.scopus.com/inward/record.url?scp=85054165958&partnerID=8YFLogxK
M3 - Artículo
SN - 0326-2383
VL - 37
SP - 1742
EP - 1750
JO - Latin American Journal of Pharmacy
JF - Latin American Journal of Pharmacy
IS - 9
ER -