The effects of the 5-HT<inf>6</inf> receptor agonist EMD and the 5-HT<inf>7</inf> receptor agonist AS19 on memory formation

A. Meneses, G. Perez-Garcia, G. Liy-Salmeron, D. Flores-Galvez, C. Castillo, E. Castillo

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Growing evidence indicates that 5-hydrohytryptamine (5-HT) receptors mediate learning and memory. Particularly interesting are 5-HT6 and 5-HT7 receptors, which are localized in brain areas involved in memory formation. Interestingly, recently selective 5-HT6 and 5-HT7 receptor agonists and antagonists have become available. Previous evidence indicates that 5-HT6 or 5-HT7 receptors antagonists had no effects, improved memory formation and/or reversed amnesia. Herein, the effects of EMD (a 5-HT6 receptor agonist) and AS19 (a 5-HT7 receptor agonist) in the associative learning task of autoshaping were studied. Post-training systemic administration of EMD (1-10 mg/kg) or AS19 (1-10 mg/kg) were tested in short-term memory (STM) and long-term memory (LTM). Results showed that only EMD 5.0 mg/kg impaired both STM and LTM. AS19 at 1-10 mg/kg significantly impaired STM but not LTM. In those groups used to test only LTM, EMD impaired it; while AS19 improved LTM. Moreover, in the interaction experiments, the STM EMD-impairment effect was partially reversed by the selective 5-HT6 receptor antagonist SB-399885 (10 mg/kg). The STM AS19-impairment effect (5.0 mg/kg) was not altered by the selective 5-HT1A antagonist WAY 100635 (0.3 mg/kg) but reversed by the selective 5-HT7 receptor antagonist SB-269970 (10.0 mg/kg). The AS19-SB-269970 combination impaired LTM. Taken together these data suggest that the stimulation of 5-HT6 impaired both STM and LTM. 5-HT7 receptors stimulation impaired STM but improved LTM. And these results are discussed in the context of their possible neural bases. © 2007 Elsevier B.V. All rights reserved.
Original languageAmerican English
Pages (from-to)112-119
Number of pages100
JournalBehavioural Brain Research
DOIs
StatePublished - 16 Dec 2008
Externally publishedYes

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Long-Term Memory
Short-Term Memory
Learning
Serotonin 5-HT1 Receptor Antagonists
Amnesia
serotonin 7 receptor
serotonin 6 receptor
Brain

Cite this

Meneses, A. ; Perez-Garcia, G. ; Liy-Salmeron, G. ; Flores-Galvez, D. ; Castillo, C. ; Castillo, E. / The effects of the 5-HT<inf>6</inf> receptor agonist EMD and the 5-HT<inf>7</inf> receptor agonist AS19 on memory formation. In: Behavioural Brain Research. 2008 ; pp. 112-119.
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The effects of the 5-HT<inf>6</inf> receptor agonist EMD and the 5-HT<inf>7</inf> receptor agonist AS19 on memory formation. / Meneses, A.; Perez-Garcia, G.; Liy-Salmeron, G.; Flores-Galvez, D.; Castillo, C.; Castillo, E.

In: Behavioural Brain Research, 16.12.2008, p. 112-119.

Research output: Contribution to journalArticle

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T1 - The effects of the 5-HT6 receptor agonist EMD and the 5-HT7 receptor agonist AS19 on memory formation

AU - Meneses, A.

AU - Perez-Garcia, G.

AU - Liy-Salmeron, G.

AU - Flores-Galvez, D.

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N2 - Growing evidence indicates that 5-hydrohytryptamine (5-HT) receptors mediate learning and memory. Particularly interesting are 5-HT6 and 5-HT7 receptors, which are localized in brain areas involved in memory formation. Interestingly, recently selective 5-HT6 and 5-HT7 receptor agonists and antagonists have become available. Previous evidence indicates that 5-HT6 or 5-HT7 receptors antagonists had no effects, improved memory formation and/or reversed amnesia. Herein, the effects of EMD (a 5-HT6 receptor agonist) and AS19 (a 5-HT7 receptor agonist) in the associative learning task of autoshaping were studied. Post-training systemic administration of EMD (1-10 mg/kg) or AS19 (1-10 mg/kg) were tested in short-term memory (STM) and long-term memory (LTM). Results showed that only EMD 5.0 mg/kg impaired both STM and LTM. AS19 at 1-10 mg/kg significantly impaired STM but not LTM. In those groups used to test only LTM, EMD impaired it; while AS19 improved LTM. Moreover, in the interaction experiments, the STM EMD-impairment effect was partially reversed by the selective 5-HT6 receptor antagonist SB-399885 (10 mg/kg). The STM AS19-impairment effect (5.0 mg/kg) was not altered by the selective 5-HT1A antagonist WAY 100635 (0.3 mg/kg) but reversed by the selective 5-HT7 receptor antagonist SB-269970 (10.0 mg/kg). The AS19-SB-269970 combination impaired LTM. Taken together these data suggest that the stimulation of 5-HT6 impaired both STM and LTM. 5-HT7 receptors stimulation impaired STM but improved LTM. And these results are discussed in the context of their possible neural bases. © 2007 Elsevier B.V. All rights reserved.

AB - Growing evidence indicates that 5-hydrohytryptamine (5-HT) receptors mediate learning and memory. Particularly interesting are 5-HT6 and 5-HT7 receptors, which are localized in brain areas involved in memory formation. Interestingly, recently selective 5-HT6 and 5-HT7 receptor agonists and antagonists have become available. Previous evidence indicates that 5-HT6 or 5-HT7 receptors antagonists had no effects, improved memory formation and/or reversed amnesia. Herein, the effects of EMD (a 5-HT6 receptor agonist) and AS19 (a 5-HT7 receptor agonist) in the associative learning task of autoshaping were studied. Post-training systemic administration of EMD (1-10 mg/kg) or AS19 (1-10 mg/kg) were tested in short-term memory (STM) and long-term memory (LTM). Results showed that only EMD 5.0 mg/kg impaired both STM and LTM. AS19 at 1-10 mg/kg significantly impaired STM but not LTM. In those groups used to test only LTM, EMD impaired it; while AS19 improved LTM. Moreover, in the interaction experiments, the STM EMD-impairment effect was partially reversed by the selective 5-HT6 receptor antagonist SB-399885 (10 mg/kg). The STM AS19-impairment effect (5.0 mg/kg) was not altered by the selective 5-HT1A antagonist WAY 100635 (0.3 mg/kg) but reversed by the selective 5-HT7 receptor antagonist SB-269970 (10.0 mg/kg). The AS19-SB-269970 combination impaired LTM. Taken together these data suggest that the stimulation of 5-HT6 impaired both STM and LTM. 5-HT7 receptors stimulation impaired STM but improved LTM. And these results are discussed in the context of their possible neural bases. © 2007 Elsevier B.V. All rights reserved.

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