Abstract
The fetotoxic potential of orally administered α-asarone was evaluated in Wistar pregnant rats given 0-25-50 and 75 mg/kg between day 6 and day 15 of gestation. The fetuses were removed for examination on day 20. A significant maternal toxicity, as indicated by reduced weight gain, was observed among pregnant dams given 50 and 75 mg/kg/day of the test material. Embryotoxic effects appeared also in the two highest treated groups, represented by the numbers of mothers and fetuses affected. However, in the 75 mg/kg treated group, significantly reduced number of fetuses per litter and decreased fetal body weights were observed.
| Translated title of the contribution | Teratological evaluation of α-asarone in rats |
|---|---|
| Original language | French |
| Pages (from-to) | 179-183 |
| Number of pages | 5 |
| Journal | Annales Pharmaceutiques Francaises |
| Volume | 46 |
| Issue number | 3 |
| State | Published - 1988 |