Teratological evaluation of α-asarone in rats

L. Jimenez, G. Chamorro, M. Salazar, N. Pages

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The fetotoxic potential of orally administered α-asarone was evaluated in Wistar pregnant rats given 0-25-50 and 75 mg/kg between day 6 and day 15 of gestation. The fetuses were removed for examination on day 20. A significant maternal toxicity, as indicated by reduced weight gain, was observed among pregnant dams given 50 and 75 mg/kg/day of the test material. Embryotoxic effects appeared also in the two highest treated groups, represented by the numbers of mothers and fetuses affected. However, in the 75 mg/kg treated group, significantly reduced number of fetuses per litter and decreased fetal body weights were observed.
Original languageAmerican English
Pages (from-to)179-183
Number of pages160
JournalAnnales Pharmaceutiques Francaises
StatePublished - 1 Jan 1988

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