Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells

Yudibeth Sixto-López, Emilie Marhuenda, Juan Benjamin García-Vazquez, Manuel Jonathan Fragoso-Vazquez, Martha Cecilia Rosales-Hernández, Oscar Zacarías-Lara, David Méndez-Luna, José Antonio Gómez-Vidal, David Cornu, Bakalara Norbert, José Correa-Basurto

Research output: Contribution to journalArticlepeer-review

Abstract

Glioblastoma multiforme (GBM) is account for 70% of all primary malignancies of the central nervous system. The median survival of human patients after treatment is around 15 months. There are several biological targets which have been reported that can be pursued using ligands with varied structures to treat this disease. In our group, we have developed several ligands that target a wide range of proteins involved in anticancer effects, such as histone deacetylase (HDACs), G protein-coupled estrogen receptor 1 (GPER), estrogen receptor-beta (ERβ) and NADPH oxidase (NOX), that were screened on bidimensional (2D) and tridimensional (3D) GBM stem cells like (GSC). Our results show that some HDAC inhibitors show antiproliferative properties at 21–32 µM. These results suggest that in this 3D culture, HDACs could be the most relevant targets that are modulated to induce the antiproliferative effects that require in the future further experimental studies.

Original languageEnglish
JournalCellular and Molecular Neurobiology
DOIs
StateAccepted/In press - 2021

Keywords

  • 3D cell culture
  • ER
  • Glioblastoma multiforme
  • GPER
  • HDAC
  • NOX

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