TY - JOUR
T1 - Tanshinones and their derivatives
T2 - Heterocyclic ring-fused diterpenes of biological interest
AU - Estolano-Cobián, Arturo
AU - Alonso, Mariana Macías
AU - Díaz-Rubio, Laura
AU - Ponce, Cecilia Naredo
AU - Córdova-Guerrero, Iván
AU - Marrero, Joaquín G.
N1 - Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - The available scientific literature regarding tanshinones is very abundant, and after its review, it is noticeable that most of the articles focus on the properties of tanshinone I, cryptotanshinone, tanshinone IIA, sodium tanshinone IIA sulfonate and the dried root extract of Salvia miltiorrhiza (TanShen). However, although these products have demonstrated important biological properties in both in vitro and in vivo models, their poor solubility and bioavailability have limited their clinical applications. For these reasons, many studies have focused on the search for new pharmaceutical formulations for tanshinones, as well as the synthesis of new derivatives that improve their biological properties. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2015) on tanshinones in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we offer an update on the last five years of new research on these quinones, focusing on their synthesis, biological activity on noncommunicable diseases and drug delivery systems, to support future research on its clinical applications.
AB - The available scientific literature regarding tanshinones is very abundant, and after its review, it is noticeable that most of the articles focus on the properties of tanshinone I, cryptotanshinone, tanshinone IIA, sodium tanshinone IIA sulfonate and the dried root extract of Salvia miltiorrhiza (TanShen). However, although these products have demonstrated important biological properties in both in vitro and in vivo models, their poor solubility and bioavailability have limited their clinical applications. For these reasons, many studies have focused on the search for new pharmaceutical formulations for tanshinones, as well as the synthesis of new derivatives that improve their biological properties. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2015) on tanshinones in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we offer an update on the last five years of new research on these quinones, focusing on their synthesis, biological activity on noncommunicable diseases and drug delivery systems, to support future research on its clinical applications.
KW - Bioavailability
KW - Biological activities
KW - Drug delivery systems
KW - Nanoparticles
KW - Solubility
KW - Synthesis
KW - Tanshinone IIA
KW - Tanshinones
UR - http://www.scopus.com/inward/record.url?scp=85101414929&partnerID=8YFLogxK
U2 - 10.2174/1389557520666200429103225
DO - 10.2174/1389557520666200429103225
M3 - Artículo de revisión
C2 - 32348220
AN - SCOPUS:85101414929
SN - 1389-5575
VL - 21
SP - 171
EP - 185
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 2
ER -