TY - JOUR
T1 - Synthetic routes of sulfonamide derivatives
T2 - A brief review
AU - Ashfaq, Muhammad
AU - Shah, Syed Shoaib Ahmad
AU - Najjam, Tayyaba
AU - Shaheen, Salma
AU - Rivera, Gildardo
PY - 2013
Y1 - 2013
N2 - Sulfonamides (SO2-NH-) have been the center of drug structures as they are quite stable and well tolerated in human beings. The sulfonamides are very important protected intermediates of amines, with several types of biological activities. Due to the broad applicability of sulfonamides, it is desirable to find general and effective methods for their synthesis. Different methods have been adopted to synthesize sulfonamides. Here is a comprehensive review which provides several of the most common and recent methods of sulfonamide synthesis: via sulfonyl chloride; starting from thiols, sulfonic acids, sulfenamide and sulfonate esters; or using indium, copper, and palladium as catalysts or Grignard reagents and metal oxides.
AB - Sulfonamides (SO2-NH-) have been the center of drug structures as they are quite stable and well tolerated in human beings. The sulfonamides are very important protected intermediates of amines, with several types of biological activities. Due to the broad applicability of sulfonamides, it is desirable to find general and effective methods for their synthesis. Different methods have been adopted to synthesize sulfonamides. Here is a comprehensive review which provides several of the most common and recent methods of sulfonamide synthesis: via sulfonyl chloride; starting from thiols, sulfonic acids, sulfenamide and sulfonate esters; or using indium, copper, and palladium as catalysts or Grignard reagents and metal oxides.
KW - Aminolysis
KW - Grignard reagent
KW - Metal oxides
KW - Route
KW - Sulfonamide
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=84892998672&partnerID=8YFLogxK
U2 - 10.2174/1570193X11310020005
DO - 10.2174/1570193X11310020005
M3 - Artículo de revisión
SN - 1570-193X
VL - 10
SP - 160
EP - 170
JO - Mini-Reviews in Organic Chemistry
JF - Mini-Reviews in Organic Chemistry
IS - 2
ER -