Synthesis of nuevamine aza-analogues by a sequence: I-MCR-aza-Diels-Alder- Pictet-Spengler

Alejandro Islas-Jácome, Luis E. Cárdenas-Galindo, Alberto V. Jerezano, Joaquín Tamariz, Eduardo González-Zamora, Rocío Gámez-Montaño

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A series of nuevamine aza-analogues were prepared in moderate to good yields in two reaction steps. The synthetic strategy involves an isonitrile-based multicomponent reaction, including an aza-Diels-Alder cycloaddition and Pictet-Spengler reaction as postcondensation.

Original languageEnglish
Pages (from-to)2951-2956
Number of pages6
JournalSynlett
Volume23
Issue number20
DOIs
StatePublished - 2012

Keywords

  • I-MCR
  • Pictet-Spengler cyclization
  • S-oxidation
  • aza-Diels-Alder
  • nuevamine aza-analogue

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