Synthesis of non-cytotoxic poly(ester-amine) dendrimers as potential solubility enhancers for drugs: Methotrexate as a case study

Delia Soto-Castro, Jorge A. Cruz-Morales, María Teresa Ramírez Apan, Patricia Guadarrama

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Abstract

This study describes the synthesis of two new families of dendrimers based on the esterification of N-alkylated 3-amine-1-propanol with two different cores, adipic acid (1stand 2ndgenerations) and ethylenediamine (generation 1.5), both with carboxylic acid end groups, offering a wide variety of further modifications at the periphery. According to the cytotoxic evaluation of the dendrimers and their possible degradation products within cell lines, these materials could be considered as innocuous. In preliminary studies, the synthesized dendrimers proved to be potential enhancers of solubility of highly hydrophobic drugs, like methotrexate, widely used in chemotherapy. © 2010 licensee MDPI Basel Switzerland.
Original languageAmerican English
Pages (from-to)8082-8097
Number of pages16
JournalMolecules
DOIs
StatePublished - 1 Nov 2010
Externally publishedYes

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