TY - JOUR
T1 - Synthesis of non-cytotoxic poly(ester-amine) dendrimers as potential solubility enhancers for drugs
T2 - Methotrexate as a case study
AU - Soto-Castro, Delia
AU - Cruz-Morales, Jorge A.
AU - Apan, María Teresa Ramírez
AU - Guadarrama, Patricia
PY - 2010/11
Y1 - 2010/11
N2 - This study describes the synthesis of two new families of dendrimers based on the esterification of N-alkylated 3-amine-1-propanol with two different cores, adipic acid (1st and 2nd generations) and ethylenediamine (generation 1.5), both with carboxylic acid end groups, offering a wide variety of further modifications at the periphery. According to the cytotoxic evaluation of the dendrimers and their possible degradation products within cell lines, these materials could be considered as innocuous. In preliminary studies, the synthesized dendrimers proved to be potential enhancers of solubility of highly hydrophobic drugs, like methotrexate, widely used in chemotherapy.
AB - This study describes the synthesis of two new families of dendrimers based on the esterification of N-alkylated 3-amine-1-propanol with two different cores, adipic acid (1st and 2nd generations) and ethylenediamine (generation 1.5), both with carboxylic acid end groups, offering a wide variety of further modifications at the periphery. According to the cytotoxic evaluation of the dendrimers and their possible degradation products within cell lines, these materials could be considered as innocuous. In preliminary studies, the synthesized dendrimers proved to be potential enhancers of solubility of highly hydrophobic drugs, like methotrexate, widely used in chemotherapy.
KW - Methotrexate
KW - Non-cytotoxic dendrimers
KW - Solubility enhancer
UR - http://www.scopus.com/inward/record.url?scp=78649457350&partnerID=8YFLogxK
U2 - 10.3390/molecules15118082
DO - 10.3390/molecules15118082
M3 - Artículo
SN - 1420-3049
VL - 15
SP - 8082
EP - 8097
JO - Molecules
JF - Molecules
IS - 11
ER -