Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis

Pedro A. Cano, Alejandro Islas-Jácome, Joaquín González-Marrero, Lilian Yépez-Mulia, Fernando Calzada, Rocío Gámez-Montaño

Research output: Contribution to journalArticle

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Abstract

The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide multicomponent reaction and their biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis are described. Reported yields are moderate to good and biological results show that these compounds could be considered as candidates to anti-parasitic drugs, especially against G. lamblia. © 2014 Elsevier Ltd. All rights reserved.
Original languageAmerican English
Pages (from-to)1370-1376
Number of pages1232
JournalBioorganic and Medicinal Chemistry
DOIs
StatePublished - 15 Feb 2014

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Giardia lamblia
Entamoeba histolytica
Azides
Pharmaceutical Preparations

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title = "Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis",
abstract = "The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide multicomponent reaction and their biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis are described. Reported yields are moderate to good and biological results show that these compounds could be considered as candidates to anti-parasitic drugs, especially against G. lamblia. {\circledC} 2014 Elsevier Ltd. All rights reserved.",
author = "Cano, {Pedro A.} and Alejandro Islas-J{\'a}come and Joaqu{\'i}n Gonz{\'a}lez-Marrero and Lilian Y{\'e}pez-Mulia and Fernando Calzada and Roc{\'i}o G{\'a}mez-Monta{\~n}o",
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Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis. / Cano, Pedro A.; Islas-Jácome, Alejandro; González-Marrero, Joaquín; Yépez-Mulia, Lilian; Calzada, Fernando; Gámez-Montaño, Rocío.

In: Bioorganic and Medicinal Chemistry, 15.02.2014, p. 1370-1376.

Research output: Contribution to journalArticle

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T1 - Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis

AU - Cano, Pedro A.

AU - Islas-Jácome, Alejandro

AU - González-Marrero, Joaquín

AU - Yépez-Mulia, Lilian

AU - Calzada, Fernando

AU - Gámez-Montaño, Rocío

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