Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis

Pedro A. Cano, Alejandro Islas-Jácome, Joaquín González-Marrero, Lilian Yépez-Mulia, Fernando Calzada, Rocío Gámez-Montaño

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Abstract

The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide multicomponent reaction and their biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis are described. Reported yields are moderate to good and biological results show that these compounds could be considered as candidates to anti-parasitic drugs, especially against G. lamblia. © 2014 Elsevier Ltd. All rights reserved.
Original languageAmerican English
Pages (from-to)1370-1376
Number of pages1232
JournalBioorganic and Medicinal Chemistry
DOIs
StatePublished - 15 Feb 2014

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