TY - JOUR
T1 - Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis
AU - Cano, Pedro A.
AU - Islas-Jácome, Alejandro
AU - González-Marrero, Joaquín
AU - Yépez-Mulia, Lilian
AU - Calzada, Fernando
AU - Gámez-Montaño, Rocío
N1 - Funding Information:
R.G.-M. thanks CONACYT for financial support (Project: CB-2011-166747-Q), also to Dr. Francisco Delgado (ENCB-IPN), Dr. Erick Cuevas (CCIQS-UAEMex) and Dr. Luis D. Miranda (IQ-UNAM) for technical support respect to HRMS, NMR and X-ray analysis respectively. Post-doctoral CONACYT Scholarship awarded to Dr. A.I.-J. ( CVU 176745 , 290662_UG , 290735_UG ) is gratefully acknowledged. P.A.C. acknowledges the CONACYT Scholarship ( 370144/304476 ).
PY - 2014/2/15
Y1 - 2014/2/15
N2 - The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide multicomponent reaction and their biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis are described. Reported yields are moderate to good and biological results show that these compounds could be considered as candidates to anti-parasitic drugs, especially against G. lamblia.
AB - The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide multicomponent reaction and their biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis are described. Reported yields are moderate to good and biological results show that these compounds could be considered as candidates to anti-parasitic drugs, especially against G. lamblia.
KW - 1,5-Disubstituted-1H-tetrazoles
KW - 3-Substituted-chromen-4-ones
KW - Anti-parasitic drug
KW - Half maximal inhibitory concentration
KW - Ugi-azide
UR - http://www.scopus.com/inward/record.url?scp=84893746554&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2013.12.069
DO - 10.1016/j.bmc.2013.12.069
M3 - Artículo
C2 - 24468633
SN - 0968-0896
VL - 22
SP - 1370
EP - 1376
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 4
ER -