Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases

Alcives Avila-Sorrosa; Alejandro Y. Bando-Vázquez; Verónica Alvarez-Alvarez; Erick Suarez-Contreras; Rocío Nieto-Meneses; Benjamín Nogueda-Torres; María Elena Vargas-Díaz; Francisco Díaz-Cedillo; Reyna Reyes-Martínez; Simon Hernandez-Ortega; David Morales-Morales

doi:10.1016/j.molstruc.2020.128520

Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases

Alcives Avila-Sorrosa, Alejandro Y. Bando-Vázquez, Verónica Alvarez-Alvarez, Erick Suarez-Contreras, Rocío Nieto-Meneses, Benjamín Nogueda-Torres, María Elena Vargas-Díaz, Francisco Díaz-Cedillo, Reyna Reyes-Martínez, Simon Hernandez-Ortega, David Morales-Morales

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).

Original language	English
Article number	128520
Journal	Journal of Molecular Structure
Volume	1218
DOIs	https://doi.org/10.1016/j.molstruc.2020.128520
State	Published - 15 Oct 2020

Keywords

Chagas disease
Crystal structures
Fluorinated schiff bases
Neglected diseases
Non-covalent molecular interactions
Trypanocidal activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.molstruc.2020.128520

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Avila-Sorrosa, A., Bando-Vázquez, A. Y., Alvarez-Alvarez, V., Suarez-Contreras, E., Nieto-Meneses, R., Nogueda-Torres, B., Vargas-Díaz, M. E., Díaz-Cedillo, F., Reyes-Martínez, R., Hernandez-Ortega, S., & Morales-Morales, D. (2020). Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases. Journal of Molecular Structure, 1218, Article 128520. https://doi.org/10.1016/j.molstruc.2020.128520

@article{b9b45eb27af248148caf06551be610e1,

title = "Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases",

abstract = "A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).",

keywords = "Chagas disease, Crystal structures, Fluorinated schiff bases, Neglected diseases, Non-covalent molecular interactions, Trypanocidal activity",

author = "Alcives Avila-Sorrosa and Bando-V{\'a}zquez, {Alejandro Y.} and Ver{\'o}nica Alvarez-Alvarez and Erick Suarez-Contreras and Roc{\'i}o Nieto-Meneses and Benjam{\'i}n Nogueda-Torres and Vargas-D{\'i}az, {Mar{\'i}a Elena} and Francisco D{\'i}az-Cedillo and Reyna Reyes-Mart{\'i}nez and Simon Hernandez-Ortega and David Morales-Morales",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = oct,

day = "15",

doi = "10.1016/j.molstruc.2020.128520",

language = "Ingl{\'e}s",

volume = "1218",

journal = "Journal of Molecular Structure",

issn = "0022-2860",

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Avila-Sorrosa, A, Bando-Vázquez, AY, Alvarez-Alvarez, V, Suarez-Contreras, E, Nieto-Meneses, R, Nogueda-Torres, B, Vargas-Díaz, ME, Díaz-Cedillo, F, Reyes-Martínez, R, Hernandez-Ortega, S & Morales-Morales, D 2020, 'Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases', Journal of Molecular Structure, vol. 1218, 128520. https://doi.org/10.1016/j.molstruc.2020.128520

TY - JOUR

T1 - Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases

AU - Avila-Sorrosa, Alcives

AU - Bando-Vázquez, Alejandro Y.

AU - Alvarez-Alvarez, Verónica

AU - Suarez-Contreras, Erick

AU - Nieto-Meneses, Rocío

AU - Nogueda-Torres, Benjamín

AU - Vargas-Díaz, María Elena

AU - Díaz-Cedillo, Francisco

AU - Reyes-Martínez, Reyna

AU - Hernandez-Ortega, Simon

AU - Morales-Morales, David

PY - 2020/10/15

Y1 - 2020/10/15

N2 - A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).

AB - A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).

KW - Chagas disease

KW - Crystal structures

KW - Fluorinated schiff bases

KW - Neglected diseases

KW - Non-covalent molecular interactions

KW - Trypanocidal activity

UR - http://www.scopus.com/inward/record.url?scp=85085581246&partnerID=8YFLogxK

U2 - 10.1016/j.molstruc.2020.128520

DO - 10.1016/j.molstruc.2020.128520

M3 - Artículo

AN - SCOPUS:85085581246

SN - 0022-2860

VL - 1218

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 128520

ER -

Synthesis, characterization and preliminary in vitro trypanocidal activity of N-arylfluorinated hydroxylated-Schiff bases

Abstract

Keywords

UN SDGs

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