TY - JOUR
T1 - Synthesis and in vitro cytocompatibility of segmented poly(ester-urethane)s and poly(ester-urea-urethane)s for bone tissue engineering
AU - González-García, Dulce María
AU - Marcos-Fernández, Ángel
AU - Rodríguez-Lorenzo, Luis M.
AU - Jiménez-Gallegos, Rodrigo
AU - Vargas-Becerril, Nancy
AU - Téllez-Jurado, Lucía
N1 - Publisher Copyright:
© 2018 by the authors.
PY - 2018/9/5
Y1 - 2018/9/5
N2 - Two series of segmented polyurethanes were obtained and their mechanical and thermal properties as well as their biodegradability and cytotoxicity were evaluated. The chemical nature of the polyurethanes was varied by using either 1,4 butanediol (poly-ester-urethanes, PEUs) or L-lysine ethyl ester dihydrochloride (poly-ester-urea-urethanes, PEUUs) as chain extenders. Results showed that varying the hard segment influenced the thermal and mechanical properties of the obtained polymers. PEUs showed strain and hardness values of about 10-20 MPa and 10-65 MPa, respectively. These values were higher than the obtained values for the PEUUs due to the phase segregation and the higher crystallinity observed for the polyester-urethanes (PEUs); phase segregation was also observed and analyzed by XRD and DSC. Moreover, both series of polymers showed hydrolytic degradation when they were submerged in PBS until 90 days with 20% of weight loss. In vitro tests using a Human Osteoblastic cell line (Hob) showed an average of 80% of cell viability and good adhesion for both series of polymers.
AB - Two series of segmented polyurethanes were obtained and their mechanical and thermal properties as well as their biodegradability and cytotoxicity were evaluated. The chemical nature of the polyurethanes was varied by using either 1,4 butanediol (poly-ester-urethanes, PEUs) or L-lysine ethyl ester dihydrochloride (poly-ester-urea-urethanes, PEUUs) as chain extenders. Results showed that varying the hard segment influenced the thermal and mechanical properties of the obtained polymers. PEUs showed strain and hardness values of about 10-20 MPa and 10-65 MPa, respectively. These values were higher than the obtained values for the PEUUs due to the phase segregation and the higher crystallinity observed for the polyester-urethanes (PEUs); phase segregation was also observed and analyzed by XRD and DSC. Moreover, both series of polymers showed hydrolytic degradation when they were submerged in PBS until 90 days with 20% of weight loss. In vitro tests using a Human Osteoblastic cell line (Hob) showed an average of 80% of cell viability and good adhesion for both series of polymers.
KW - Biodegradable polymers
KW - Cytocompatibility
KW - Human osteoblastic cells
KW - Polyurethanes
UR - http://www.scopus.com/inward/record.url?scp=85052933533&partnerID=8YFLogxK
U2 - 10.3390/polym10090991
DO - 10.3390/polym10090991
M3 - Artículo
C2 - 30960916
SN - 2073-4360
VL - 10
JO - Polymers
JF - Polymers
IS - 9
M1 - 991
ER -