Synthesis and characterization of two danazol derivatives

Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, Maria López-Ramos, Elodia Garcia-Cervera

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two danazol derivatives were synthesized and characterized by spectral analyses. In order to characterize the structural and chemical requirements of danazol derivatives, several parameters such as logP, π, Rmand Vm were evaluated. The results showed an increase in the values of logP for the compound 6 in comparison with 3. The compound 3 showed an increase in the values of π, Rmand Vm with respect to 6. These data indicate a high degree of lipophilicity and a low steric impediment for compound 6 in comparison with 3.
Original languageAmerican English
JournalE-Journal of Chemistry
StatePublished - 1 Dec 2010
Externally publishedYes

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Figueroa-Valverde, L., Díaz-Cedillo, F., López-Ramos, M., & Garcia-Cervera, E. (2010). Synthesis and characterization of two danazol derivatives. E-Journal of Chemistry.
Figueroa-Valverde, Lauro ; Díaz-Cedillo, Francisco ; López-Ramos, Maria ; Garcia-Cervera, Elodia. / Synthesis and characterization of two danazol derivatives. In: E-Journal of Chemistry. 2010.
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Figueroa-Valverde, L, Díaz-Cedillo, F, López-Ramos, M & Garcia-Cervera, E 2010, 'Synthesis and characterization of two danazol derivatives', E-Journal of Chemistry.

Synthesis and characterization of two danazol derivatives. / Figueroa-Valverde, Lauro; Díaz-Cedillo, Francisco; López-Ramos, Maria; Garcia-Cervera, Elodia.

In: E-Journal of Chemistry, 01.12.2010.

Research output: Contribution to journalArticle

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T1 - Synthesis and characterization of two danazol derivatives

AU - Figueroa-Valverde, Lauro

AU - Díaz-Cedillo, Francisco

AU - López-Ramos, Maria

AU - Garcia-Cervera, Elodia

PY - 2010/12/1

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N2 - Two danazol derivatives were synthesized and characterized by spectral analyses. In order to characterize the structural and chemical requirements of danazol derivatives, several parameters such as logP, π, Rmand Vm were evaluated. The results showed an increase in the values of logP for the compound 6 in comparison with 3. The compound 3 showed an increase in the values of π, Rmand Vm with respect to 6. These data indicate a high degree of lipophilicity and a low steric impediment for compound 6 in comparison with 3.

AB - Two danazol derivatives were synthesized and characterized by spectral analyses. In order to characterize the structural and chemical requirements of danazol derivatives, several parameters such as logP, π, Rmand Vm were evaluated. The results showed an increase in the values of logP for the compound 6 in comparison with 3. The compound 3 showed an increase in the values of π, Rmand Vm with respect to 6. These data indicate a high degree of lipophilicity and a low steric impediment for compound 6 in comparison with 3.

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Figueroa-Valverde L, Díaz-Cedillo F, López-Ramos M, Garcia-Cervera E. Synthesis and characterization of two danazol derivatives. E-Journal of Chemistry. 2010 Dec 1.