Synthese directe d'indoles anti-hypertensifs

L. Gerardo Zepeda, Mirna Rojas-Gardida, Martha S. Morales-Rios, Pedro Joseph-Nathan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The direct syntheses of two potencial anti-hypertensive drug candidates having the indole skeleton (2 and 3), using the β-cyanoaldehyde 6 or a γ-amide-aldehyde in Fischer condesations with ρ{variant}-methoxyphenylhydrazine are described. As by-products from these syntheses we isolated the chloropyrrole (11) and two diasteroisomeric molecules (12-E and 12-Z), one of them leading selectivity to the N-acetylpyrrole 13. The structure and stereochemistry of three of these minor products (10, 12-E and 14) were confirmed by single crystal X-ray diffraction studies.

Original languageFrench
Pages (from-to)6439-6448
Number of pages10
JournalTetrahedron
Volume45
Issue number20
DOIs
StatePublished - 1989
Externally publishedYes

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