TY - JOUR
T1 - Synergistic antinociceptive interaction between acetaminophen or metamizol and B vitamins in the formalin test
AU - Terán-Rosales, Flavio
AU - Medina-Santillán, Roberto
AU - Reyes-García, Gerardo
AU - Granados-Soto, Vinicio
PY - 2005/12
Y1 - 2005/12
N2 - There is evidence that B vitamins produce antinociception in animals. However, potentiation of NSAID-induced antinociception by B vitamins is unclear. The current study was designed to investigate the antinociceptive interaction between a mixture of B vitamins and either acetaminophen or metamizol. Acetaminophen (56-316 mg/kg), metamizol (32-1 78 mg/kg), and the mixture of B vitamins (32-178 mg/kg of thiamine, pyridoxine, and cyanocobalamin in a 100:100:1 proportion, respectively) or a combination of each drug with the B vitamins mixture was administered orally to female Wistar rats, and the antinociceptive effect determined in the formalin test. Isobolographic analyses were used to define the nature of the interaction between NSAIDs and B vitamins. Oral administration of either drug produced a dose-related antinociceptive effect. Isobolographic analyses revealed that both acetaminophen or metamizol and the B vitamins mixture interacted synergistically in the formalin test, suggesting that these two combinations could be useful in treating inflammatory pain states.
AB - There is evidence that B vitamins produce antinociception in animals. However, potentiation of NSAID-induced antinociception by B vitamins is unclear. The current study was designed to investigate the antinociceptive interaction between a mixture of B vitamins and either acetaminophen or metamizol. Acetaminophen (56-316 mg/kg), metamizol (32-1 78 mg/kg), and the mixture of B vitamins (32-178 mg/kg of thiamine, pyridoxine, and cyanocobalamin in a 100:100:1 proportion, respectively) or a combination of each drug with the B vitamins mixture was administered orally to female Wistar rats, and the antinociceptive effect determined in the formalin test. Isobolographic analyses were used to define the nature of the interaction between NSAIDs and B vitamins. Oral administration of either drug produced a dose-related antinociceptive effect. Isobolographic analyses revealed that both acetaminophen or metamizol and the B vitamins mixture interacted synergistically in the formalin test, suggesting that these two combinations could be useful in treating inflammatory pain states.
KW - Acetaminophen
KW - Antinociception
KW - B vitamins
KW - Metamizol
KW - Synergy
UR - http://www.scopus.com/inward/record.url?scp=33646401130&partnerID=8YFLogxK
U2 - 10.1002/ddr.20071
DO - 10.1002/ddr.20071
M3 - Artículo
AN - SCOPUS:33646401130
SN - 0272-4391
VL - 66
SP - 286
EP - 294
JO - Drug Development Research
JF - Drug Development Research
IS - 4
ER -