TY - JOUR
T1 - Synergistic antiallodynic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats
AU - Mixcoatl-Zecuatl, Teresa
AU - Quiñónez-Bastidas, Geovanna N.
AU - Caram-Salas, Nadia L.
AU - Ambriz-Tututi, Mónica
AU - Araiza-Saldaña, Claudia I.
AU - Rocha-González, Héctor I.
AU - Medina-Santillán, Roberto
AU - Reyes-Garcia, Gerardo
AU - Granados-Soto, Vinicio
PY - 2008
Y1 - 2008
N2 - Anticonvulsants, including gabapentin and carbamazepine, have shown activity against several types of neuropathic pain; however, they have limiting side effects that may minimize their use. In this study the possible synergistic interaction between anticonvulsants and benfotiamine or cyanocobalamin on spinal nerve ligation-induced tactile allodynia was assessed. Oral administration of gabapentin (15-300 mg/ kg), carbamazepine (10-300 mg/kg), benfotiamine (30-600 mg/kg) or cyanocobalamin (0.3-6.0 mg/kg) significantly reduced tactile allodynia in rats. Maximal antiallodynic effects were reached with gabapentin 300 mg/kg (∼70%), carbamazepine 300 mg/kg (∼66%), benfotiamine 600 mg/kg (∼51%) and cyanocobalamin 6 mg/kg (∼59%). At the highest tested doses, gabapentin, but not carbamazepine, benfotiamine or cyanocobalamin, significantly reduced motor coordination. Coadministration of gabapentin or carbamazepine with benfotiamine or cyanocobalamin in a fixed ratio markedly reduced spinal nerve ligation-induced tactile allodynia, showing a synergistic interaction between anticonvulsants and B vitamins. Data indicate that combinations of anticonvulsants with benfotiamine or cyanocobalamin are able to reduce tactile allodynia without affecting motor coordination in rats, and suggest the possible clinical use of these combinations in the treatment of neuropathic pain in humans.
AB - Anticonvulsants, including gabapentin and carbamazepine, have shown activity against several types of neuropathic pain; however, they have limiting side effects that may minimize their use. In this study the possible synergistic interaction between anticonvulsants and benfotiamine or cyanocobalamin on spinal nerve ligation-induced tactile allodynia was assessed. Oral administration of gabapentin (15-300 mg/ kg), carbamazepine (10-300 mg/kg), benfotiamine (30-600 mg/kg) or cyanocobalamin (0.3-6.0 mg/kg) significantly reduced tactile allodynia in rats. Maximal antiallodynic effects were reached with gabapentin 300 mg/kg (∼70%), carbamazepine 300 mg/kg (∼66%), benfotiamine 600 mg/kg (∼51%) and cyanocobalamin 6 mg/kg (∼59%). At the highest tested doses, gabapentin, but not carbamazepine, benfotiamine or cyanocobalamin, significantly reduced motor coordination. Coadministration of gabapentin or carbamazepine with benfotiamine or cyanocobalamin in a fixed ratio markedly reduced spinal nerve ligation-induced tactile allodynia, showing a synergistic interaction between anticonvulsants and B vitamins. Data indicate that combinations of anticonvulsants with benfotiamine or cyanocobalamin are able to reduce tactile allodynia without affecting motor coordination in rats, and suggest the possible clinical use of these combinations in the treatment of neuropathic pain in humans.
KW - Benfotiamine
KW - Carbamazepine
KW - Cyanocobalamin
KW - Gabapentin
KW - Synergistic interaction
KW - Tactile allodynia
UR - http://www.scopus.com/inward/record.url?scp=56049122474&partnerID=8YFLogxK
U2 - 10.1358/mf.2008.30.6.1254247
DO - 10.1358/mf.2008.30.6.1254247
M3 - Artículo
SN - 0379-0355
VL - 30
SP - 431
EP - 441
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology
IS - 6
ER -