1H NMR metabolomic signatures related to giant cell tumor of the bone

Francisco Javier Martínez-López, Angel E. Bañuelos-Hernández, Elvia Becerra-Martínez, Eduardo Santini-Araujo, Ruben A. Amaya-Zepeda, Elizabeth Pérez-Hernández, Nury Pérez-Hernández

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Abstract

© 2017 The Royal Society of Chemistry. Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the1H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications.
Original languageAmerican English
Pages (from-to)45385-45392
Number of pages8
JournalRSC Advances
DOIs
StatePublished - 1 Jan 2017

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Tumors
Bone
Nuclear magnetic resonance
Tissue
Biosynthesis
Phospholipids
Metabolites
Metabolism
Amino acids
Amino Acids
Metabolomics

Cite this

Martínez-López, F. J., Bañuelos-Hernández, A. E., Becerra-Martínez, E., Santini-Araujo, E., Amaya-Zepeda, R. A., Pérez-Hernández, E., & Pérez-Hernández, N. (2017). 1H NMR metabolomic signatures related to giant cell tumor of the bone. RSC Advances, 45385-45392. https://doi.org/10.1039/c7ra07138h
Martínez-López, Francisco Javier ; Bañuelos-Hernández, Angel E. ; Becerra-Martínez, Elvia ; Santini-Araujo, Eduardo ; Amaya-Zepeda, Ruben A. ; Pérez-Hernández, Elizabeth ; Pérez-Hernández, Nury. / 1H NMR metabolomic signatures related to giant cell tumor of the bone. In: RSC Advances. 2017 ; pp. 45385-45392.
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abstract = "{\circledC} 2017 The Royal Society of Chemistry. Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the1H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications.",
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Martínez-López, FJ, Bañuelos-Hernández, AE, Becerra-Martínez, E, Santini-Araujo, E, Amaya-Zepeda, RA, Pérez-Hernández, E & Pérez-Hernández, N 2017, '1H NMR metabolomic signatures related to giant cell tumor of the bone', RSC Advances, pp. 45385-45392. https://doi.org/10.1039/c7ra07138h

1H NMR metabolomic signatures related to giant cell tumor of the bone. / Martínez-López, Francisco Javier; Bañuelos-Hernández, Angel E.; Becerra-Martínez, Elvia; Santini-Araujo, Eduardo; Amaya-Zepeda, Ruben A.; Pérez-Hernández, Elizabeth; Pérez-Hernández, Nury.

In: RSC Advances, 01.01.2017, p. 45385-45392.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - 1H NMR metabolomic signatures related to giant cell tumor of the bone

AU - Martínez-López, Francisco Javier

AU - Bañuelos-Hernández, Angel E.

AU - Becerra-Martínez, Elvia

AU - Santini-Araujo, Eduardo

AU - Amaya-Zepeda, Ruben A.

AU - Pérez-Hernández, Elizabeth

AU - Pérez-Hernández, Nury

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N2 - © 2017 The Royal Society of Chemistry. Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the1H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications.

AB - © 2017 The Royal Society of Chemistry. Giant cell tumor of the bone (GCTB) is an osteolytic neoplasm of uncertain biological behavior that affects the epiphyseal ends of long bones in young adults. This study describes for the first time the1H NMR untargeted metabolic profiling of tissues from GCTB, which is clearly different from tissue controls. Applying univariate and multivariate analysis, fourteen differential metabolites were determinate and the major disturbed metabolic pathways included glycero-phospholipid metabolism and amino acid biosynthesis. These metabolic differences contribute to understand the molecular basis of GCTB and represent potential markers with future clinical applications.

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DO - 10.1039/c7ra07138h

M3 - Article

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SN - 2046-2069

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Martínez-López FJ, Bañuelos-Hernández AE, Becerra-Martínez E, Santini-Araujo E, Amaya-Zepeda RA, Pérez-Hernández E et al. 1H NMR metabolomic signatures related to giant cell tumor of the bone. RSC Advances. 2017 Jan 1;45385-45392. https://doi.org/10.1039/c7ra07138h