TY - JOUR
T1 - Sub-basal increases of GABA enhance the synthesis of TNF-α, TGF-β, and IL-1β in the immune system organs of the Nile tilapia
AU - Nájera-Martínez, Minerva
AU - López-Tapia, Brenda P.
AU - Aguilera-Alvarado, G. Paulina
AU - Madera-Sandoval, Ruth L.
AU - Sánchez-Nieto, Sobeida
AU - Giron-Pérez, Manuel Iván
AU - Vega-López, Armando
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/11/15
Y1 - 2020/11/15
N2 - The cells of the immune and neuronal systems share different receptors for cytokines or neurotransmitters, producing feedback responses between both systems. Cytokines such as IL-1β and TNF-α can induce inflammation; however, the secretion of these molecules can be modulated by anti-inflammatory cytokines, as is the case for TGF-β, as well as by different hormones or neurotransmitters such as the γ-aminobutyric acid (GABA). In this study, we evaluated the secretion of IL-1β, TNF-α, and TGF-β under basal conditions, in the head of the kidney, spleen, thymus, and serum of the Nile tilapia, as well as their release induced by different sub-basal increases of GABA. We found that at the higher dose of GABA these cytokines were synthesised at a higher concentration compared to the control group. These results may suggest that there is feedback between both systems and that GABA plays a role in the modulation of the immune response.
AB - The cells of the immune and neuronal systems share different receptors for cytokines or neurotransmitters, producing feedback responses between both systems. Cytokines such as IL-1β and TNF-α can induce inflammation; however, the secretion of these molecules can be modulated by anti-inflammatory cytokines, as is the case for TGF-β, as well as by different hormones or neurotransmitters such as the γ-aminobutyric acid (GABA). In this study, we evaluated the secretion of IL-1β, TNF-α, and TGF-β under basal conditions, in the head of the kidney, spleen, thymus, and serum of the Nile tilapia, as well as their release induced by different sub-basal increases of GABA. We found that at the higher dose of GABA these cytokines were synthesised at a higher concentration compared to the control group. These results may suggest that there is feedback between both systems and that GABA plays a role in the modulation of the immune response.
KW - Cytokines
KW - GABA
KW - Immunomodulation
KW - Neurotransmitters
KW - Oreochromis niloticus
UR - http://www.scopus.com/inward/record.url?scp=85090414729&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2020.577382
DO - 10.1016/j.jneuroim.2020.577382
M3 - Artículo
C2 - 32919148
AN - SCOPUS:85090414729
SN - 0165-5728
VL - 348
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577382
ER -